Via Care Community Health Center's Chicas: My Life, Nuestro Camino program is an integrated culturally competent treatment response to substance use disorders and/or co-occurring mental disorders (SUD/COD) among underserved high-risk Latinas (HRL) in and around East Los Angeles neighborhoods who are at risk or living with HIV/AIDS. (Los Angeles County is one of the localities hardest hit by the HIV epidemic in the U.S) The goals of Chicas are: (1) to improve health, functioning, and stability of HRL through collaborative, comprehensive, trauma-informed, and recovery-based clinical and peer support services that address behavioral and physical health, as well as other needs driven by social determinants of health (SDOH) factors; and (2) to reduce infection and transmission rates of HIV and viral hepatitis (VH) among HRL and their sexual and drug-using partners. More than 50% of Chicas clients will be justice-involved; 50% will be immigrants; 30% monolingual Spanish-speaking; 5% transgender or nonbinary; 20% lesbian or bisexual; 100% low-income (under 200% of the FPL); 25% unhoused/housing insecure; and 20% women who inject drugs. HRL from East LA neighborhoods experience disparities in access, use, and outcomes of health care due to a variety of SDOH factors (e.g., housing instability, gender-based violence, gangs and justice system involvement, language, racism, immigration status, trans-/homophobia, stigma regarding SUD/COD and HIV, the culture of machismo, etc.). There is a dearth of culturally competent SUD/COD services integrated into programs and organizations that specifically address the needs of women in the catchment area, especially those who have experienced gender-based violence and PTSD. Objectives include screening for SUD/COD and HIV/VH and linking immediately and successfully into care coordination services; ensuring high rates of retention in the Seeking Safety EBP and clinical services to address PTSD and substance misuse; improving linkage to HIV care, PrEP uptake, and treatment/medication adherence among HRL; successfully linking HRL to a medical home; and improving mental health and decreasing substance misuse, thereby increasing functioning, self-efficacy, social connection/inclusion, and a sense of hope for participants. A total of 350 unduplicated HRL will be served (50 in Year 1 and 75 in each subsequent year) through this grant. Additionally, 1,400 HRL and their partners will be screened for HIV, 840 screened for SUD/COD, 420 will be enrolled in Seeking Safety, and 420 will receive case management and/or recovery support services.