St. John's Well Child and Family Center's (DBA St. John's Community Health) TransConnect Program will integrate, enhance, and expand screening, assessment, evidence-based harm reduction, treatment and recovery support services for substance use disorder & co-occurring mental disorders (SUD/COD) among low-income transgender/gender nonconforming (TGNC) adults in South Los Angeles. More than 75% of clients will be people of color; 25% homeless/unstably housed; 40% immigrants; 27% best served in Spanish; and 10% justice-involved; 25% are transmasculine, 65% transfeminine and 10% nonbinary. TGNC experience SUD/COD at disproportionately high rates of posttraumatic stress as a result of experiences of poly-victimization, discrimination, and depression/anxiety due to struggles with gender dysphoria. TransConnect will provide an opportunity to address SUD and support clients to improve their health, functioning and stability through collaborative, comprehensive, trauma-informed, peer driven services, including implementation of the Seeking Safety EBP adapted for TGNC. Objectives include: ensuring staff/partners have all training needed to conduct services in a way that is trans-affirming and culturally competent; linking positive screens immediately into care coordination services where TGNC will work with a provider on an individual service plan; ensuring high rates of retention in Seeking Safety and clinical care; and increasing a sense of hope, functioning, self-efficacy, and social connection for participants. A total of 375 TGNC will be served (125 annually). A total of 1,500 TGNC will be screened, 300 will be enrolled in Seeking Safety, and 375 will access case management and/or recovery support services.