Project FRIEND Connect will provide medication assisted treatment (MAT) and comprehensive psychosocial services to 150 individuals aged 18 or older with opioid use disorder (OUD). Project FRIEND Connect is an extension of the current Project FRIEND: First Responder Increased Education and Naloxone Distribution initiative, San Francisco’s emergency medical systems (EMS)-based leave-behind naloxone program in which EMS staff dispense naloxone in the pre-hospital setting to persons they deem at high risk for opioid overdose. Project FRIEND Connect will specifically focus on a population of patients who have experienced an overdose event, received naloxone, and did not receive MAT initiation. Patient Navigators will work to link and retain each enrolled patient in outpatient care using continency management and motivational interviewing. Three evidence-based practices, known to be effective with the population of focus, will be used to accomplish program goals: MAT pharmacotherapy, patient navigation with motivational interviewing, and contingency management. The project’s goals are to (1) increase MAT initiation in pre-hospital patients who experience an opioid overdose event, (2) reduce the impact of OUD on enrolled patients, and (3) increase access and engagement with psychosocial support services. The project will link patients to San Francisco’s centralized Treatment Access Program and an outpatient MAT-providing clinic with services ranging from individual counseling, mental health services, to recovery support services. During this project, multiple performance indicators will be measured with SAMHSA’s required GPRA assessments. Project FRIEND Connect key staff are currently core team members of the current Project FRIEND leave-behind naloxone program, as well as come from the city’s safety and public hospital’s Departments of Emergency Medicine and Family & Community Medicine. Project staff are highly trained individuals who are state and nationally recognized leaders in the treatment of OUD.