New Mexico (NM) is ideally positioned to expand its capacity to address the opioid use disorder crisis through implementation of evidence-based practices in prevention, treatment, recovery and harm reduction through use of the SOR funds. It will additionally include training and technical assistance to support agencies to address stimulant use disorder. The New Mexico State Opioid Response-2020 (NMSOR-2020) will continue to expand capacity to address OUD morbidity and mortality via the modified Hub and Spoke model (Collaborative Hubs Model) to support the adoption and implementation of EBPs statewide that have proven effectiveness to prevent, treat, support recovery and reduce harm related to OUD. NMSOR-2020 will support services across a broad range of ages, and cultural and ethnic groups, including Native American communities and Hispanic populations. The overarching goal of NMSOR-2020 is to reduce OUD rates and overdose deaths. To accomplish this, NMSOR-2020 has the following specific goals: (1) Increase access to medication-assisted treatment (MAT) using three FDA-approved medications for the treatment of OUDs; (2) Ensure MAT is comprehensive and includes FDA approved medications, therapy, and recovery supports; (3) Expand access to evidence-based prevention activities; (4) Expand tribal focused opioid use disorder education efforts; (5) Expand access to recovery services, including peer supports; and (6) Ensure continuous quality improvement through quality data collection, reporting & evaluation. We will accomplish these goals by expanding upon the NM Collaborative Hubs approach. Collaborative Hub partners will provide: Comprehensive MAT services for persons with OUD; Evidence based prevention services in primary and secondary schools; awareness and engagement in MAT using a statewide media campaign; Training in use of naloxone for harm reduction and engagement of survivors of overdose in MAT (buprenorphine and methadone treatments); Training and support to health care workforce (primary care, behavioral health, recovery), first responders on use of naloxone to help reverse overdose; and training in all components of MAT including DATA waiver, safer opioid prescribing, psychosocial supports (e.g. Motivational Interviewing, Community Reinforcement Approach, ASAM criteria 1-3) and recovery supports with a focus on expansion of peer recovery services. Training and technical assistance for providers/agencies will include Contingency Management to address stimulant use disorder and increase engagement in care. The GPRA tool will be collected on all individuals receiving treatment services through NMSOR, with 500 persons reached annually, and 1000 persons over the life of the 2 year grant.