This project addresses a critical need in Ohio’s opioid mitigation strategy by creating a sustainable opioid prevention framework that compliments existing treatment and recovery efforts in the state. The Ohio Prevention Partnership (OPP) is a collaboration between The Ohio State University and local community partners to develop sustainable community teams who deliver coordinated implementation of quality evidence-based and evidence-informed opioid prevention programs in high-need communities. Our project will leverage OPP’s experience creating community prevention frameworks and use SAMHSA’s Strategic Prevention Framework (SPF) to assess local community partners’ technical capacity to plan and implement successful community-forward programs. Once communities are assessed, OPP will help communities form multi-disciplinary teams committed to a shared interest in opioid prevention programming. OPP will then guide the community in selecting evidence-based and/or evidence-informed opioid prevention programs from the broad categories of family-based parent/child relationship skill building, school-based youth resilience training, youth and adult mental health crisis identification and response training, and prescription opioid safety. This project will serve some of the highest need rural communities in Ohio, a state that has led the nation in overdose deaths for six consecutive years.