The Ponca Tribe of Oklahoma proposes the implementation of a comprehensive opioid and stimulant prevention campaign by applying a strategic, multi-tiered approach targeting relevant stakeholders (e.g. tribal administration, elders, at-risk youth, etc.) within White Eagle and surrounding tribal communities. Prevention activities will blend cultural wisdom with evidenced-based practices for substance abuse prevention to supplement existing MAT activities intended to mitigate rates of opioid misuse and abuse amongst AI/AN persons. Provisions will also be made to conduct prevention activities for locally identified drugs of abuse, specifically methamphetamine. A culturally tailored opioid and stimulant prevention campaign will be developed in collaboration with the above stakeholders and guidance from the Substance Abuse and Mental Health Services Administration’s (SAMHSA) Strategic Prevention Framework. Further, the Ponca Tribe of Oklahoma proposes to expand the scope of psychosocial services offered by the White Eagle Health Center, Behavioral Health Department as a supplement to the Cognitive Behavioral Therapy (CBT) and case management services presently offered. The WEHC and its physician(s) will continue to deliver MAT services using the Office-Based Opioid Treatment (OBOT) model which mandates enrolled patients receive appropriate referral for adjunctive therapy. The expanded scope of psychosocial services is proposed to include peer-recovery support, psychoeducation, and culturally appropriate mutual-support group meetings. Such activities will be facilitated via direct-care and/or telebehavioral health platforms. The Ponca Tribe of Oklahoma proposes to provide MAT services to approximately 10 unduplicated AI/AN persons ages 15-years-old and older annually and approximately 20 unduplicated AI/AN people ages 15-years-old and older over the two (2) year grant project period. These patients will be in addition to the patients presently served by the TOR grant received in 2019. Additionally, the Ponca Tribe anticipates to document contact with a minimum of 500 AI/AN persons and other community members via the proposed opioid and stimulant misuse/abuse prevention campaign during the two (2) year grant project.