The North Broward Hospital District dba Broward Health is proposing the Broward Health Emergency Department Alternatives to Opioids (BH ED-ALT) Project to develop and implement alternatives to opioids for pain management within the Broward Health hospital system and ED. The population to be served are vulnerable and/or underserved populations residing in Broward County. The target population is defined as persons age 18+ who may belong to low socioeconomic status (SES), and, who are seeking treatment for conditions classified by International Classification of Diseases (ICD) codes M54.5 (Low back pain) and G43.909 (Migraine). Key strategies/interventions of the project will include the development of treatment protocols by a multi-disciplinary team that will include staff from Pharmacy, ED, Palliative Care/ Pain Management, Population Health/ Care Coordination, and Rehabilitation Services. The protocols will include a complete physical examination to accurately describe the medical condition and pain experienced by the individual, examination for the presence of co-occurring mental and/or substance use disorders, supporting appropriate laboratory studies to assist in diagnosis and identification of current opioid medication and other substance use, physical therapy, cognitive-behavioral therapy interventions, and other alternative approaches that may assist in pain management without the use of opioids. The measurable objectives of the proposed project include: the development of team-based treatment protocols in year 1, as well as training and service delivery. Annually, the project will reach 150 persons belonging to the population of focus, of which 75 unduplicated participants will be enrolled. Throughout the lifetime of the project: 60 staff member will be trained; the project will have reached 450 persons belonging to the population of focus; enrolled 225 unduplicated participants, defined as per the population of focus; achieved 50% program compliance among participants; as needed, provide linkage to evidence-based MAT, access to care under Broward Health’s Financial Assistance Program, and/or Ryan White program services to 90% patients identified; and have catalogued and shared project results with 6 local and/or national healthcare organizations.