Southern Plains Tribal Health Board's CARA Project will serve Native American/American Indians residing in designated rural areas of Oklahoma. The goals of the project are to increase availability of opioid overdose reversal medications to first responders and community members. Secondary goals are to train and provide resources for first responders and members of other key sectors on carrying and administering naloxone; to train and provide resources for first responders and other community members of safety around fentanyl, carfentanyl, and other dangerous drugs to protect themselves from exposure; and establish processes for referral to appropriate treatment and recovery communities. We will train 200 first responders per year, for a total of 800 individuals; provide outreach activities to 1,000 tribal families per year for a total of 4,000 families; and reach 18,000 Native American adults per year through media campaigns, for a total of 72,000 individuals. Objectives are to convene an advisory group to oversee implementation, provide annual opioid awareness educational opportunities across five target communities to 150 key community leaders, develop 15 written strategic partnerships with tribal first responder agencies to implement naloxone policies and procedures, provide 25 community trainings for 200 first responders annually, purchase 1,008 naloxone kits, purchase and disseminate materials for continued naloxone trainings to 14 partners annually, develop online training resources, promote use and training of ODMAP in training events, promote trainings and gather feedback through website and social media, create and implement public education campaign, assist partners with policy development regarding safety precautions around fentanyl, coordinate training and strategic planning sessions for four main healthcare partners to establish crisis intervention protocol, assist CIT with creating outreach and referral materials to be administered to 250 families of individuals receiving naloxone, provide education to 25 policy makers on the utility of a 911 Good Samaritan Law. The following tribal counties will be served: Cheyenne and Arapaho (Blaine, Custer, Washita), with a Native population of 2.8%; Comanche Nation (Caddo, Kiowa), with a Native population of 19.6%; Chickasaw Nation (Bryan, Johnston, Carter, Pontotoc), with a Native population of 10.5% and; Absentee Shawnee Tribe (Pottawatomi), with a Native Population of 15.1%.