New Mexico Strategic Prevention Framework Partnerships for Success 2025 - ABSTRACT Strategic Prevention Framework--Partnerships for Success for States (SPF-PFS) FOA No. SP-25-003, CFDA No. 93.243 SAMHSA Center for Substance Abuse Prevention Office of Substance Abuse Prevention, Behavioral Health Services Division Health Care Authority, State of New Mexico The New Mexico Health Care Authority, Behavioral Health Services Division, Office of Substance Abuse Prevention will implement SAMHSA's Strategic Prevention Framework Partnerships for Success initiative in four New Mexico counties with more than 40 overdose deaths in 2023, and a rate of more than 40 overdose deaths per 100,000. The project will address polysubstance misuse, which led to 64% of all overdose deaths in the state. The project will address polysubstance misuse with the goal of reducing overdose from the concurrent use of opioids, including prescription, fentanyl, heroin, and methamphetamine, alcohol, cocaine and benzodiazepines. New Mexico will implement a polysubstance use indicated prevention initiative, designed to tear down the common siloes that limit flexible responses to what people who use drugs actually experience. Sixty-four percent of all overdoses in New Mexico in 2023 are polysubstance overdoses. New Mexico will focus this effort on adults aged 25 to 64 - especially Hispanic and Native American men -- who have the highest rates of overdose death, and high school aged youth (14 to 18) and college-aged and young adults (18 to 24) who are homeless or housing-unstable. These groups have the highest opioid use rates of all youth subpopulations and will soon be adults with high-risk behaviors that include polysubstance use. The four prioritized counties have 59% the state’s overdoses within their borders. Those counties are Bernalillo, Santa Fe, San Juan, and Rio Arriba. New Mexico will implement a range of evidence-based indicated prevention programs and harm reduction strategies to address New Mexico’s polysubstance use crisis. Each of the four county coalitions will, through the Strategic Prevention Framework process, select evidence-based strategies that address their needs and populations and that fit their capacity. Objectives: • Reduce the self-reported prevalence of polysubstance use among adults aged 25 to 64, and among homeless and housing-unstable youth and young adults • Reduce self-reported reported binge drinking among adult opioid users, and among homeless and housing-unstable youth and young adults • Reduce concurrent use of illicit methamphetamine and any opioids among adults • Increase the perception of harm of using two substances within one hour New Mexico’s population of focus includes Hispanic and Native Americans men 25 to 64 years of age – estimated to be 167,409 in the four prioritized counties, and homeless and housing unstable youth aged 14 to 24 years of age, estimated to be around 10,401 persons in the four-county area, for a total population of focus of 177,810 persons. A range of indicated prevention strategies will be utilized, including SBIRT, Motivational Interviewing, and Contingency Management programs.