The Wyoming Survey & Analysis Center (WYSAC) is uniquely qualified to provide training and technical assistance (T/TA) to the substance misuse prevention community in the Department of Health and Human Service (HHS) Region 8 through the establishment of a Mountain Plains Prevention Technology Transfer Center (Region 8 PTTC) at the University of Wyoming, in partnership with the Educational Development Center, Inc. (EDC). The target population for the PTTC at the University of Wyoming will include key state and local prevention professionals, coalition members, pre-professionals desiring to enter the field, Tribal members, and other interested parties. With a total of six related State agencies, 281 counties, and 29 Tribes, many with prevention coalitions and staff, we estimate serving at least as 2,000 unique individuals each year, with a target of 15,000 over the lifetime of the collaborative agreement. Goals for the PTTC at the University of Wyoming include the delivery of high-quality T/TA to the substance misuse prevention workforce in Region 8 and across the country, supporting and building the substance misuse prevention workforce in Region 8 and across the country through collaboration and communication with State agencies, Tribal nations, and the PTTC network, and advancing the substance misuse prevention field through subject matter expertise in data collection, needs assessment, process and outcome evaluation, data visualization, and the development of a Prevention Fellowship program. WYSAC fills a gap in the current PTTC system with special expertise in data collection, needs assessment, process and outcome evaluation, data visualization, and the use of applied prevention research to improve the quality of interventions, trainings, and other prevention services.