The WV Strategic Prevention Framework-Partnerships for Success (SPF-PFS) grant will focus on selective and indicated prevention practices statewide to prevent tobacco, vaping, marijuana, and alcohol use and prescription misuse among high-risk students in underserved communities. An entirely Appalachian state with more than 80% of its rural population living in rugged terrain and a fourth of its children living in poverty, WV has the highest fatal overdose rate and per capita cost of "deaths of despair" in the country, as well as higher youth tobacco and alcohol use and higher young adult opioid use disorder and depression than the national average. This grant will enhance the state's prevention workforce's ability to make data-informed decisions and implement effective practices and policies that will improve the life trajectories of its children, youth, and young adults. It is anticipated that at least 1,000 high-risk students will be served per grant year, or 5,000 over the life of the grant.