The Keeping ICT SAFE (Substance Abuse Prevention Focusing on Empowerment) will 1) reduce e-cigarette use among youth (12-17) and young adults (18-24) in Sedgwick County, 2) reduce the onset and progression toward opioid use among youth and young adults in Sedgwick County, and 3) promote mental health education and awareness and reduce mental health stigma in Sedgwick County. The proposed partnership will implement three evidence-based approaches the Truth campaign to address e-cigarette and opioid use and misuse, the Catch Your Breath curriculum, and Mental Health First Aid to promote mental health in the community. A community needs and assets assessment will be conducted to determine the needs and assets of the community to set priorities. Once the priorities are set, key stakeholders will be brought together (youth, families, providers, etc.) to make data driven decisions. The social media campaigns will be designed by youth and we expect to reach over 10,000 youth in our county using social media platforms (i.e., Instagram, Tik Tok, Youtube, etc.) over the five year period to bring awareness and connect youth with valuable resources. Keeping ICT SAFE will work with community-based organizations to implement the evidence-based curriculums and reach the underserved populations in our community.