The Substance Use and HIV Navigation project (SUHN) will reduce health disparities for racial/ethnic minority adults from subpopulations (MSM, MSMW, LGBTQ+) by providing substance use prevention (25 unduplicated in year 1, increasing to 55 in year 5) and HIV prevention (30 unduplicated in year 1, increasing to 85 in year 5) for individuals at high-risk for substance use disorders (SUDs) and HIV infection, who are not in stable housing and/or reside in communities with high rates of HIV, Viral Hepatitis (VH), and/or Sexually Transmitted Infections (STIs). By using evidence-based practices for SUDs and HIV prevention strategies, expected outcomes for the populations of focus include decreased use of substances through SUD/COD treatment; increased HIV testing and diagnosis of HIV for individuals with or at risk for SUD/COD; an increase in these individuals linked to and retained in HIV medical care toward sustained viral suppression; and linkage to stable housing. The SUHN Project will be based on the Strategic Prevention Framework (SPF) by designing and implementing a comprehensive strategic plan to address SUD/COD and HIV/VH/STI among the population of focus by conducting an initial needs assessment, building capacity, and assessing project performance.