To address the ongoing public health emergencies of substance misuse and mental health distress in Arizona, the Governor’s Office for Youth, Faith, and Family propose a partnership with Arizona State University to establish the Arizona Prevention and Wellbeing Improvement Collaborative (PWIC). The mission of PWIC is to create a collaborative network of community organizations focused on preventing substance use and increasing mental wellbeing among youth and young adults from underserved minority groups (particularly Native American and Hispanics/Latinos). Beginning in Year One and based on the results of a community health assessment, PWIC will recruit thirty eligible organizations to participate in a five-year collaborative. Across the five years, all thirty organizations will have access to expert- and peer-led education, tailored technical assistance, an online training certificate program, and quality improvement support. Using a peer learning model, organizations will teach one another how they learned to adopt an evidence-based program or to improve an existing one. PWIC will offer a two-tiered incentive strategy to support organizations toward full participation and improvement. Organizations will receive the top incentive by attending all group education and technical assistance sessions, graduating five staff members through the training certificate program, and submitting all improvement action plan files a week before the deadline. PWIC success will be primarily measured by the number of organizations that qualify for the top incentive. Building off previous efforts to expand capacity for community-based prevention, PWIC will be the first collaborative in Arizona designed to promote evidence-based substance use prevention through peer learning and quality improvement support. PWIC will succeed by building relationships between community organizations, promoting community cohesion, and empowering participants to adopt evidence-based practice.