With funding from SAMHSA's Harm Reduction Program, St. John's Community Health (SJCH) proposes to establish comprehensive harm reduction services for low-income Latinx and Black/African American people (˜ 98% of population of focus) who use drugs (PWUD) residing in South Los Angeles. Many of our participants will be uninsured, undocumented, homeless/housing insecure, LGBTQ+, reentry, and have a substance use disorder (SUD) with co-occurring mental disorder (COD), HIV, and/or viral hepatitis. Our multi-modality, trauma-informed, peer-driven harm reduction program (HRP) will delivered by expertly trained staff at Avalon Health and Access Center, on our Homeless Services Mobile Clinic, during street-based outreach, and integrated into our continuum of programs that target similar populations. Services will include: overdose prevention education/naloxone distribution, syringe services, support services, and linkage to comprehensive services that address medical, behavioral health, and other social determinants of health-driven needs. Annual numbers of individuals to be served are 1,600 in Year, 2,500 in Year 2, and 3,000 in Year 3; a total of 4,000 unduplicated participants will receive services by our HRP. Our overarching goal to reduce the impact of drug-related harm in South LA through expanding access to comprehensive harm reduction services. Objectives include: (1) establishing the South LA Harm Reduction Right to Health Committee comprised of harm reduction service providers, PWUD, individuals in recovery, other residents impacted by substance use, and key community members; (2) conducting community-driven needs assessment, strategic and sustainability planning, policies and procedures development, and staff training on harm reduction best practices and evidence-based interventions to be used; (3) piloting, launching, and evaluating HRP services, engaging in quality improvement strategies to ensure the program is responsive to community need; and (4) designing and executing culturally and linguistically relevant public awareness campaigns addressing SUD/PWUD stigma and promoting widespread community naloxone access and distribution.