Project Freedom South: Preventing Opioid Overdose-Related Deaths is training first responders - public safety, fire, and EMS personnel - in south Alabama to prevent opioid overdose-related deaths. Goal 1: Increase access to naloxone, reduce the number of adverse opioid-related events, and increase awareness of substance use treatment services in the catchment area, by reducing the number of opioid overdoses and opioid overdose deaths in the catchment area by 5% by the end of the project; distributing >5,000 naloxone kits and determining the number of opioid overdose reversals within the catchment area across the 5 years of the project; maintaining a 100% referral rate for substance use treatment services among patients who experience an opioid overdose reversal; and maintaining a > 50% treatment initiation rate across the 5 years of the project for individuals who are referred to substance use treatment services; Goal 2: Increase knowledge about opioid overdose primary/secondary prevention strategies within the catchment area, by offering the following in each year of the project >=30 trainings on overdose death prevention strategies, training >=12 medical professional agencies on the risks of overprescribing, training >=24 first responder agencies on overdose reversal drugs, and >=6 open community trainings on opioid overdose prevention strategies; ensuring that >=50% of participants at trainings report learning new information/skills; determining whether>=50% of the participants at the trainings plan to use the information/skills learned, feel confident in using the skills learned, and can identify overdose symptoms; and maintaining a >=50% success rate in opioid overdose reversals on first responder service runs for opioid overdose. Goal 3: Describe how, where, and by whom various naloxone types are used in the catchment area, by reporting in each year of the project the number and type of naloxone kits used in each administration of naloxone, the dollar amount and percentage of the total budget used to purchase naloxone products, the number of referrals to a kit prescriber following the successful reversal of an opioid overdose, the number of persons administering naloxone by community affiliation, demographics, number of prior administrations, and Census tract, the number of naloxone patients in our catchment area by location of administration, demographics, number of prior administrations, and Census tract, and the number of naloxone kits distributed in each zip code by request/response status, whether or not the distribution was to a household, dosage amount, type of recipient, and type of kit. Goal 4: Identify neighborhoods in the catchment area with the highest opioid overdose rates, by determining hotspots of opioid overdose first responder service runs in the catchment area in each year of the project using geographic information system (GIS) software and latitude/longitude data for each service run. The unduplicated training count will be 780 annually for a total of 3,900 individuals, including first responders, medical and treatment professionals, and family members over the five-year project period.