The NATIVE Roots Program is a Native cultural revitalization community-level project that will serve Indigenous youth in grades 4-12 and their schools in the Oklahoma City and Norman area. Led by the Southern Plains Tribal Health Board (SPTHB), that connects with 43 federally recognized Tribes across Oklahoma, Kansas and Texas, the goals of this project are to reduce alcohol and prescription drug misuse among NA/AI youth, enhance data access and utilization for the expansion of AI/AN focused prevention services, reduce gaps in stakeholder capacity to provide services to AI/AN youth, and increase AI/AN safe and supportive spaces in schools. This will be accomplished through a variety of environmental strategies, primarily focused on creating culturally responsive schools that better meet the needs of AI/AN students. The objectives of this project are as follows: increase percentage of AI/AN youth reporting they perceive risk of alcohol use and opioid misuse, increase percentage of AI/AN youth who report they disapprove of peers using alcohol, provide an annual epidemiological outcomes report, reach 16,000 people with media advocacy program, implement training curricula for 100 school level faculty and staff, see 500 unique visitors to online training platform annually, provide Prevention Day gathering to train 200 AI/AN youth and 50 AI/AN adults, increase number of schools implementing the NATIVE Roots comprehensive school program to 15, provide technical assistance to four (4) on-campus AI/AN clubs, conduct curriculum review for four (4) schools to ensure AI/AN content is appropriately discussed, host an annual youth Leadership Institute to serve approximately 100 youth, and increase percentage of youth reporting school connectedness and cultural awareness. Through effective process and outcome evaluation and the development of protocols, we will expand the NATIVE Roots trainings for school personnel and AI/AN youth throughout the Oklahoma City and Norman area. A data workgroup will conduct extensive assessment to inform a media advocacy campaign, and we will develop an online training portal for adults to learn cultural competencies in working with AI/AN youth. The AI/AN population of OKC grades 4-12 is estimated to be as many as 38,709 students. We anticipate reaching approximately 16,000 through media advocacy, training and education materials and directly serving approximately 1,000 people each year. We anticipate serving approximately 85,000 people through the life of the project.