The overall goal of the proposed Region 9 Prevention Technology Transfer Center (PTTC), hereafter referred to as the Pacific Desert PTTC, is to advance Region 9’s substance abuse prevention workforce’s ability to identify, select, plan for, implement, and evaluate evidence-based and promising substance abuse prevention interventions/practices (EBI/Ps) to achieve a reduction in substance misuse and harmful consequences. This will be achieved by strengthening regional alliances among culturally diverse professionals, pre-professionals, researchers, policy-makers, and funders and delivering state-of-the-art, culturally-relevant TTA services, innovative web-based tools, and proven workforce development services that reflect regional needs, thereby increasing quality and expanding access to training and technical assistance (TTA) services. The Pacific Desert will serve the substance abuse prevention field, including professionals/pre-professionals, organizations, and others (e.g., state, county, and community prevention leaders and staff, prevention coalition directors and member agency representatives; social services; the medical community; community- and faith-based organizations; and gender and sexual-minority serving organizations). The Pacific Desert will promote local, regional, and national communication and collaboration; improve prevention professionals’ prevention knowledge and skills to implement evidence-based interventions and promising practices; enhance TTA services through continuous learning opportunities and innovative web-based products; strengthen the prevention workforce through leadership development opportunities and curriculum infusion packages on prevention science for college courses; and evaluate the impact of TTA services and resources across the region. A spectrum of innovative low to high intensity TTA services will be provided such as web-based or onsite training, phone and/or onsite consultations, communities of practice, trainings-of-trainers, self-paced online courses, podcasts, guidance documents, toolkits, and other products. Topics for services and products (e.g., implementing EBI/Ps; using the Strategic Prevention Framework; applying prevention science; preventing opioid misuse/overdose) will be identified by Region 9 prevention professionals through an annual needs assessment and through frequent communication with state and local prevention professionals via an Advisory Council and regional expert advisory committees. Pacific Desert staff have particular expertise in epidemiological needs assessments and evaluation, and trainings and resources on this topic will be developed and disseminated nationally. To increase overall impact and utility, TTA will be designed in a sequenced manner using a mix of in-person, web-based, and phone modalities. Guidance documents, tools, and other products on innovations in prevention science will be available on the Pacific Desert webpages and in hard copy form. Over the course of the five-year project, the Pacific Desert will serve no less than 4,644 people (no less than 595 people in Year 1 due to project start-up and no less than an average of 1,012 people per year in Years 2-5).