The University of Missouri-Kansas City (UMKC) has convened a stellar partnership between the National Association of State Alcohol and Drug Abuse Directors, Inc. (NASADAD), National Prevention Network (NPN) and the Applied Prevention Science International (APSI) to serve as the Prevention Technology Transfer Centers (PTTC) Network Coordinating Center (NCC). This partnership will serve SAMHSA, the 12 Centers (10 Regional and 2 Population-Specific), and the substance use prevention field across America. The NCC team represents a unique and strong collaboration between the technology transfer network expertise and infrastructure of the existing Addiction Technology Transfer Center (ATTC) Network Coordinating Office (NCO) at UMKC, the state-level knowledge and reach of NASADAD through the NPN, and the prevention science and knowledge transfer experts at APSI. The NCC’s primary population of focus is the PTTC Network. The NCC serves as the backbone to the Network, principally focusing on building the capacity and deepening the impact of the PTTCs themselves. The NCC anticipates serving 1,730 participants as follows: Y1-330; Y2-470; Y3-310; Y4-310; Y5-310. Over the five-year period of the grant, the NCC will serve 8,650 participants. The NCC will address the following goals: develop and enhance strategic alliances among culturally diverse practitioners, researchers, policy makers, & community leaders to stretch scarce resources; increase and optimize opportunities for the PTTCs to build the prevention workforce; establish a collaborative, coordinated Network approach, based on implementation science strategies, to improve the quality of substance use prevention efforts. These goals will be accomplished through the development of a national strategic plan focused on delivering culturally and linguistically appropriate science base prevention interventions. The NCC will serve as the focal point for the PTTC Network in identifying opportunities for regional and national alliances. The NCC will develop, implement and participate in activities that will upgrade the standards of professional practice for the prevention workforce by implementing evidence-based prevention interventions. The NCC will increase access to publicly available, free of charge training and technical assistance to the prevention field. The NCC will host an interactive website, a searchable PTTC Network products clearing house and online courses through an accessible e-learning platform. The NCC will work collaboratively with the other SAMHSA funded TTCs to leverage resources and expand the collective impact of the TTCs. Building this Network from on-the-ground, state-level know-how combined with evidence-based prevention practices will maximize the NCCs ability to affect real-world practice change, leading to more effective prevention efforts.