Tarzana Treatment Centers, Inc. (TTC) will provide substance abuse, HIV and hepatitis prevention education, HIV and hepatitis testing, and navigation services to high-risk youth in Los Angeles County (LAC). The proposed project, Valley Street Smart, will target racial/ethnic minority youth 13-24, with a special focus on young males who have sex with males (YMSM), homeless youth, and other youth at high risk for HIV and substance abuse. The proposed catchment area for the project is Service Planning Area (SPA) 2, namely the San Fernando Valley, which is in the northwest section of LAC. Latino and African-American youth, especially YMSM, in SPA 2 are disproportionately affected by HIV and SUD and are in need of targeted prevention education and navigation services. TTC will partner with two agencies renowned for their work with high-risk youth in SPA 2, The Village Family Services and Penny Lane Centers, to provide these vital services. Prior to the commencement of services, a targeted needs assessment and strategic plan will be completed with the aim of increasing local capacity to respond to the SUD, HIV and hepatitis prevention needs of high-risk minority youth. Local agencies, community-based organizations, advocacy groups, youth, and other community stakeholders will be involved in the process and subsequent design of effective and sustainable prevention interventions and strategies, which will translate into improved outcomes for youth in terms of SUD, HIV and hepatitis rates. Through the creation of a Youth Advisory Board, Valley Street Smart will involve youth in the design and implementation of prevention education and environmental strategies, including social media and social marketing tools, which will enhance and sustain prevention efforts in SPA 2 during and beyond the project period. TTC will implement the evidence-based SUD/HIV prevention education intervention Street Smart to provide youth with the knowledge, skills, and confidence to advocate for their own HIV and SUD prevention needs. Peer Support Specialists will serve as prevention navigators providing intensive case management and navigation services for those participants who need assistance in accessing vital services, such as HIV care and prevention, benefits assistance, SUD treatment, mental health, and housing. A total of 540 high-risk youth (60 in Year 1 and 120 annually thereafter) will receive the ten-week prevention education intervention, and at least 50% of those or 270 high-risk youth (30 in Year 1 and 60 annually thereafter) will receive navigation services during the five-year project period. All high-risk youth will be tested for HIV and hepatitis and screened for SUD, mental health, primary care, benefits assistance, housing, and other ancillary service needs. TTC will leverage existing resources and activities for HIV prevention and care at TTC as well as a broad network of community partners to ensure participants who are HIV positive receive the appropriate services and support to maintain their health and recovery and that all high-risk HIV negative participants have access to biomedical prevention services.