The Pueblo of San Felipe (SF) has incredibly high rates of suicidal ideation and behavior. In the recent CDC Youth Risk and Resiliency survey 21.3% of SF high school and 44.4% of middle school students reported that they seriously considered suicide and 16.2% of high school students and 18.2% of middle school students reported that they attempted suicide in the past year compared to 19% and 7% respectively statewide. SF has made significant progress raising awareness about youth suicide prevention over the past 15 years of GLS funding. However, prior grants have not focused on youth involved with Family Services for abuse and neglect, a high need population that warrants specialized attention. Furthermore, there has never been a specific focus on assisting youth who identify as LGBTQIA+ and are a higher risk for suicidality. Finally, prevention services have not been fully integrated with local School Based Health Center primary care services, and other child and youth serving organizations. Thus, San Felipe GLS (SF GLS) will focus on Native American (NA) youth experiencing mental illness, co-occurring substance use disorders, and/or suicidality. The purpose of SF GLS is to implement youth (up to age 24) suicide prevention and early intervention strategies in schools, educational institutions, juvenile justice systems, substance use programs, mental health programs, foster care systems, pediatric health programs, and other SF child- and youth-serving organizations. The goals of SF GLS are to: (1) increase the number of youth-serving organizations who are able to identify and work with youth at risk of suicide; (2) increase the capacity of clinical service providers to assess, manage, and treat youth at risk of suicide; (3) improve the continuity of care and follow-up of youth identified to be at risk for suicide, including those who have been discharged from emergency department and inpatient psychiatric units; and (4) utilize a continuous quality improvement (CQI) approach to ensure that data informs decision-making. These goals will be accomplished by implementing evidence-based prevention and intervention programming in five schools and in collaboration with all child and youth-serving organizations working with SF youth and families. Activities will include behavioral health promotion activities such as Teen and Youth Mental Health First Aid, and school based promotion activities such as the SF developed Katishtya Intergenerational Cultural Knowledge Seminars (KICKS); universal screening using the PHQ-9 and AUDIT-C; clinical intervention using Cognitive Behavioral Therapy for Suicide Prevention, Counseling on Access to Lethal Means, and Zero Suicide; and instituting continuity of care practices across child and youth serving organizations to ensure smooth transitions into crisis and inpatient services and back to community-based treatment. SF GLS is expected to serve 800 NA youth with promotion and prevention activities, 200 with behavioral health screens, and 75 with direct services annually. SF GLS will also provide MHFA, YMHFA, and other related trainings to 100 community members, youth-serving organization staff and school personnel annually, thereby ensuring breadth and depth of services.