The Culture, Connection, & Healing for Urban Indigenous Families project will serve American Indian (AI) youth ages 9 - 24 and their parents/caregivers. Proposed interventions will address substance misuse and suicide among AI families in Maricopa County and increase resiliency factors through evidence-based curriculum, coalition work, and community-based prevention education. It is estimated that the project will provide direct services to 1,675 youth, parents/caregivers and AI service providers over the project lifetime. Programs to be implemented are the Living in 2 Worlds (L2W), Parenting in 2 Worlds (P2W) curriculum, Gathering of Native Americans (GONA) workshops, historical intergenerational trauma workshops, safeTALK, ASIST, QPR, and community-based coalition activities. Abbreviated goals and objectives of the project are: Goal 1: Increase resiliency in urban AI youth and families. Objective 1.1: By the end of each year, 15 urban AI middle-school youth in the Phoenix area will increase by 3% their use of the R.E.A.L drug resistance strategies to resist drugs taught in the evidence-informed L2W as measured by baseline pre- and post-survey data for each of the 5 years. Objective 1.2: By the end of each year, 60 AI youth/young adults between 9-24 in the Phoenix area will report increased positive development through participation in culturally appropriate workshops, such as storytelling, ribbon skirt making, and drumming, as measured by participant counts, satisfaction surveys and a retrospective survey for each of the 5 years. Objective 1.3: By the end of each calendar year, for the target group of urban AI youth ages 9 - 24 in the Phoenix area, increase the number of youth/young adults trained in evidence-based suicide and substance abuse prevention programming eg. GONA, QPR, ASIST and safeTALK by 200 participants each year. Goal 2: Improve family functioning and communication strategies among parents/caregivers, siblings, and urban AI youth. Objective 2.1: By the end of each year, for the target group of urban AI families, increase cultural skills as a protective factor as measured by at least 60% of adult participants attending 80% of P2W workshop. Objective 2.2: By the end of each year, for the target group of 30 urban AI families, increase by 5% the communication skills and number of drug prevention resistance strategies taught to their children (as taught in P2W) to improve family functioning and communication as measured by pre-survey data collected the beginning of year 1 compared to post-survey data at the end of each of the 5 years. Goal 3: Increase the capacity of local AI-serving organizations to respond to high-risk behaviors among AI youth that may contribute to AI youth suicide and substance use disorder risk. Objective 3.1: By the end of year 1, AI youth and family-serving organizations will meet quarterly to develop standards, policies and procedures for youth at-risk of suicide and substance use disorder; AI youth-serving organizations will meet biannually in each subsequent grant year to review and revise policies and procedures as needed. Objective 3.2: By the end of year 1, AI-serving organizations will develop an action plan that focuses on selective prevention and intervention strategies based on the results of the Community Systems Analysis, Needs Assessment and Readiness Assessment; implementation of the Action Plan will continue through each remaining year of the grant. Objective 3.3: By the end of each year, 30 AI-serving and youth-serving providers will increase 5% their knowledge on historical/generational trauma affecting AIs in Maricopa County as evidenced by retrospective reflection survey. Objective 3.4: Each calendar year, hold the Suicide Prevention Convening annually to increase communication across service-provider agencies through the continuation of the suicide convening of youth, parents and health professionals as measured by satisfaction forms and participation counts.