The State University of New York (SUNY) Downstate Health Sciences University (DHSU) proposes to conduct the "STAR Health Center Integrated Care Project" The project will be implemented by the Special Treatment and Research (STAR) Program, at both sites of the SHC Health Center (SHC), the STAR Program's trauma-informed, co-located outpatient primary care and behavioral health program for adults (18 and older) (www.starprogrm.nyc). The SHC's flagship site, STAR-Downstate, is located in Suite J of SUNY-DHSU's University Hospital of Downstate in E. Flatbush. SHC's 2nd outpatient site, STAR-Brookdale, is located at One Brooklyn Health-Brookdale Hospital Medical Center in East NY. This area is underserved with respect to primary and mental health (MH) care and HIV rates are disproportionately high. The populations of focus, Black & Latinx adults (18+) with a serious mental illness (SMI) or co-occurring disorder (COD) living with or at risk for HIV and/or hepatitis, have complex health care and treatment needs. SUNY-DHSU and Brookdale serve a densely urban service area populated by low-income, predominantly (over 75%) Black (including African-American, Afro-Caribbean & African immigrant) and Latinx (20%) populations. Barriers to care include poverty, homelessness, unemployment, & lack of education &/or health insurance. Brooklyn ranks 1st in NYC for new HIV diagnoses (411 or 29.4%). AIDS diagnoses (248 or 27%), and concurrent HIV/AIDS diagnoses (95 or 35.4%). Nearly 12.4% of Brooklyn's cumulative AIDS cases among women are directly attributable to injection drug use (IDU) (10% among males); many more heterosexual & MSM cases are indirectly attributable to substance use. Interventions include: 1) providing in-reach and outreach to inform individuals of available HIV & hepatitis prevention and MH services; 2) providing evidence-based mental and substance use disorder (SUD) treatment and practices that are trauma-informed and recovery-oriented (e.g., Motivational Interviewing (MI); Cognitive Behavioral Therapy (CBT), 3) rapid HIV and HCV screening and HAV/HBV vaccinations; 4) PEP/PrEP; 5) comprehensive, interdisciplinary on-site HIV, hepatitis and MH care; 6) peer support services; and 7) case management. Goals: 1) identify adults with a SMI or COD living with or at risk for HIV and/or hepatitis; 2) implement evidence-based interventions (e.g., MI, CBT); 3) provide HIV and hepatitis screening and hepatitis vaccinations; and 4) engage and retain those testing positive for HIV and/or hepatitis and/or SUD/COD in primary care and BH services at the SHC. Objectives include providing inreach and outreach to identify eligible clients; HIV and hepatitis prevention services of care, including MH, primary care health, and HIV and hepatitis treatment, and other and linkage to care, peer support and case management to coordinate all aspects supportive services (e.g., housing, benefits, employment) for 100% of newly-identified positives; implementing MI/CBT for 100% of eligible clients. Numbers to be Served: 50 persons each in Year 1; 100 each in Yrs. 2 and 3; and 50 in Yr. 4 (total of 300 over 4 years).