Henry Ford Health System proposes a comprehensive Zero Suicide model across all 9 emergency departments serving diverse populations in urban, suburban, and rural areas across 4 counties in Southeastern and Southcentral Michigan, including Detroit and its surrounding metropolitan area. The rate of suicide across Michigan is 15.0/100,000, higher than the national average, and is over 20.0/100,000 in the rural Jackson County area. Henry Ford is widely recognized for developing and implementing Zero Suicide in 2001 and subsequently demonstrated a >75% reduction in suicide among behavioral health patients. This reduction has been sustained for nearly 2 decades, including multiple years with zero suicides among all behavioral health patients. This program and these data have been used to support widespread adoption of Zero Suicide across the nation and around the world. Henry Ford expanded Zero Suicide to primary care settings as part of a comprehensive Behavioral Health Integration program in 2010. The program has since leveraged virtual technology and integrated in-person visits to provide real-time clinical assessment, safety planning, care coordination, psychotherapy, and other treatment for patients who screen positive for suicide. The proposed program in this application would support implementation of all 7 Zero Suicide elements within all 9 Emergency Departments. The program would leverage current screening requirements as part of standard nursing triage for all patients admitted to the ED to stimulate a clinical suicide risk assessment completed in-person or via telemedicine to ensure real-time immediate access and optimize shared staffing for all EDs via a team of physicians, clinical psychologists, social workers, and nurses. This process would also include a comprehensive safety plan, re-assessment and monitoring, and treatment planning for transition between settings. It would expand Behavioral Health Integration using a combination of telemedicine and standard processes to support post-discharge care coordination, caring contacts, and suicide treatment. A Zero Suicide training program for emergency room and behavioral health integration personnel will be implemented by experienced faculty. The emergency department is among the most important settings for suicide prevention, identification of risk, and initiation of treatment. The important new Joint Commission guidelines have increased requirements for suicide prevention in emergency settings. The proposed model would not only provide support to expand services across Henry Ford, but also help establish a model that could be disseminated and sustained across diverse settings throughout the US. Given our partnerships with national and international health and suicide prevention leaders, this model could be rapidly disseminated to other systems. Priority has always been to develop sustainable models of care, so that they can be implemented and sustained broadly. The embedded evaluation team has expertise evaluating large scale and multi-site Zero Suicide implementation, and has an extensive history collaborating with health system leaders to use research and evaluation data for rapid-cycle decisions and quality improvement.