The Comanche Nation is a federally recognized tribe located in southwest Oklahoma serving 17,479 citizens and members of surrounding communities. We are not located on a traditional reservation but rather reside in bicultural communities under shared jurisdictions with Oklahoma governmental systems. The cycle of addiction, poverty, barriers to care, historical and intergenerational trauma, and other significant risk factors for substance use disorder has created a breakdown of individual and family relationships extending across generations within our tribal community. The crisis of substance misuse has intensified as the opioid epidemic has worsened in our area, with usage prevalent in 7 out of 10 homes. Comanche Nation’s Community Opioid Intervention Pilot Project will incorporate programming to conduct a tribal needs assessment and develop a strategic action plan based on the identified priorities. Proposed activities to support the plan include: (1) raising public awareness of opioid use disorder through development of culturally responsive materials/resources and a targeted awareness campaign based; (2) creating a broader support network for individuals and families and the programmatic infrastructure needed for those services; and (3) increasing access to treatment by broadening the availability of MAT in our region and providing cultural competency training to service providers. Our goal is for these initiatives to create an integrated continuum of care across prevention, treatment, and recovery using the intra-tribal and community partnership approach that we are implementing with this project.