The Oklahoma State University Center for Health Sciences' National Center for Wellness and Recovery (NCWR) will provide planning, expertise, services, and continued support for rural communities engaged in activities to combat substance use disorder (SUD), including opioid use disorder (OUD). The purpose of the proposed project is to reduce the morbidity and mortality of SUD and OUD in Okmulgee County, Oklahoma, a high-risk, rural community. Okmulgee County is among the top 15 counties (out of 77) in the State of Oklahoma for unintentional poisoning, and nearly three-fourths of the deaths involved a prescription pain killer. The overall goal of the proposed project is to strengthen and expand SUD/OUD prevention, treatment, and recovery (PTR) services to enhance access to treatment and move towards recovery. The proposed work plan and strategies will be carried out over the next three years of funding and beyond by a purposeful, multi-sectoral community-based coalition, with representatives from all sectors of the targeted community. The NCWR will serve as the Implementation project convener, working closely with an existing community-based coalition in Okmulgee County.