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HAPLN1 mediates collagen remodeling during aging to influence melanoma and immune cell motility

Award Number: F99CA212437
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/21/2016
PERIOD OF PERFORMANCE END DATE: 08/31/2017

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HAPLN1 mediates collagen remodeling during aging to influence melanoma and immune cell motility - Project Summary The increased aggressiveness of melanoma in elderly patients leads to increased metastasis and therapy resistance in these patients. Our goal in this proposed research is to understand the molecular mechanisms underlying age-related increases in melanoma metastasis, as well as effects on the immune microenvironment. Our overall hypothesis is that aged patients have changes in the extracellular matrix (ECM) of the skin that leads to differential motility of melanoma and the immune cells in the tumor. To test this hypothesis, we will undertake two specific aims that are outlined in the research proposal. The proposed studies are based on my findings from my previous studies that aging affects the metastasis in melanoma cells. My work identified various proteins that are de-regulated during aging, and our data showed a 35-fold decrease in levels of a collagen crosslinking protein, HAPLN1, during aging. Firstly, we will assess the effect of collagen crosslinking mediated by HAPLN1 on mediating the changes in migration of melanoma cells from the tumor. Secondly, we will focus on changes in the infiltration of lymphocytes into the tumor when age-related changes in HAPLN1 levels restructure the tumor ECM. We expect this research to generate targets for therapeutic implications in elderly melanoma patients. Apart from these goals, this NCI Predoctoral to Postdoctoral Fellow Transition Award will allow me to develop expertise in cancer research while providing me with funding to support my postdoctoral training. My training plan outlined in this proposal will take advantage of the extensive resources available to me at The Wistar Institute and University of the Sciences in the F99 phase of my training. During this phase, my training will be overseen by my mentor, Dr. Ashani Weeraratna who has successfully mentored several postdoctoral and clinical fellows in their academic careers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$4,722 )
2021	2016	UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	600 S 43RD ST	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Research Manpower	000	1	2/25/2021	NEW	-$4,722
														Subtotal = -$4,722

Issue Date FY: 2016 ( Subtotal = $45,076 )
2016	2016	UNIVERSITY OF THE SCIENCES IN PHILADELPHIA	43RD STREET / KINGSESSING AVE	PHILADELPHIA	PA	19104	PHILADELPHIA	USA	Cancer Research Manpower	000	1	9/21/2016	NEW	$45,076
														Subtotal = $45,076

Grand Total All Awards = $40,354

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HAPLN1 mediates collagen remodeling during aging to influence melanoma and immune cell motility

Award Number: F99CA212437

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/21/2016

PERIOD OF PERFORMANCE END DATE: 08/31/2017

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