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Hormonal regulation of value-based decision-making

Award Number: F32MH125448
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 11/16/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2021

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Hormonal regulation of value-based decision-making - Project Summary Individuals decide between alternatives based on their perceived value of the reward associated with each option. In humans, this value-based decision-making behavior varies by sex and across the menstrual cycle. However, it is not understood how endogenous sex hormones influence the neural dynamics that underlie decision-making. 17b-estradiol, the principle estrogenic hormone that varies in expression across the menstrual cycle, is a compelling candidate because it is known to activate dopaminergic signaling in the nucleus accumbens, a key center for reward processing in the brain. This work will address two questions: 1) What is the effect of 17b-estradiol on rats’ value-based decision-making? 2) What is the in vivo mechanism by which 17b-estradiol modulates dopaminergic signaling during value-based decision-making behavior? This project will address these questions with state-of-the-art tools, including fiber photometry imaging, mass spectrometry, and cutting-edge computational methods. It will characterize the interactions between 17b-estradiol and dopamine signaling in rats performing a novel value-based decision-making behavior in naturally cycling females, in ovariectomized females with and without an exogenous dose of 17b-estradiol, and in males. This proposal will establish how 17b-estradiol affects the behavioral engagement of the dopaminergic system and the dynamics of downstream circuits in rats performing a rich, quantifiable value-based decision-making behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$16,850 )
2023	2020	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Mental Health Research Grants	000	1	11/23/2022	NEW	-$16,850
														Subtotal = -$16,850

Issue Date FY: 2022 ( Subtotal = -$19,764 )
2022	2020	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Mental Health Research Grants	000	1	11/18/2021	NEW	-$19,764
														Subtotal = -$19,764

Issue Date FY: 2020 ( Subtotal = $69,554 )
2020	2020	NEW YORK UNIVERSITY	70 WASHINGTON SQ S	NEW YORK	NY	10012	NEW YORK	USA	Mental Health Research Grants	000	1	9/16/2020	NEW	$69,554
														Subtotal = $69,554

Grand Total All Awards = $32,940

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Hormonal regulation of value-based decision-making

Award Number: F32MH125448

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 11/16/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2021

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