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Representational code and causal mechanisms of prefrontal regulation of emotion

Award Number: F32MH113347
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/01/2017
PERIOD OF PERFORMANCE END DATE: 04/12/2020

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Representational code and causal mechanisms of prefrontal regulation of emotion - PROJECT SUMMARY Emotion-regulatory deficits are a hallmark of mood and anxiety disorders. Thus, the ability to regulate emotional responses according to one's goals and to effectively override automatic responses to emotional events is paramount to mental health and wellbeing. Function of the lateral prefrontal cortex (LPFC) has been shown to play a pivotal role in supporting goal-oriented and flexible behavior. Moreover, extant data implicates LPFC dysfunction in the pathophysiology of depression and anxiety. However, studies establishing the specific and causal contributions of LPFC function to emotion regulation are sorely lacking. This proposal will illuminate the causal role of LPFC representations for goal-oriented behavioral regulation during affective processing and identify mediating neural mechanisms. The proposed studies will test the central hypothesis that task-relevant emotion-regulatory goals are dynamically represented in mid-LPFC, from which they are conveyed to topographically organized dorsomedial PFC (dmPFC) and integrated with affect signals from the amygdala. This hypothesis is based on recent insights into PFC organization and documented neuroanatomical projections. The experiments will employ a behavioral task that is sensitive to LPFC function and that indexes the degree of influence of prepotent emotional stimuli on behavior depending on the task goal. The LPFC- dmPFC-amygdala circuitry will be examined using a combination of advanced neuroimaging multi-voxel pattern analysis (MVPA) combined with transcranial magnetic stimulation (TMS), and behavioral studies of patients with focal PFC lesions. This combination of novel data acquisition methods and analytic approaches will reveal the functional causal contributions of specific PFC regions and provide a precise mechanistic account of how the LPFC contributes to adaptive emotional responding. The proposed studies will thus fill a substantial gap in emotion regulation research, and further the development of a model that can be applied to optimize and personalize treatment for individuals who suffer from mood and anxiety disorders associated with PFC dysfunction.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$344 )
2023	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Mental Health Research Grants	000	3	10/17/2022	NON-COMPETING CONTINUATION	-$344
														Subtotal = -$344

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Mental Health Research Grants	002	3	9/29/2022	NON-COMPETING CONTINUATION	$975
2022	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Mental Health Research Grants	001	3	4/22/2022	NON-COMPETING CONTINUATION	-$975
2022	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Mental Health Research Grants	000	2	4/22/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $63,746 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Mental Health Research Grants	000	3	3/19/2019	NON-COMPETING CONTINUATION	$63,746
														Subtotal = $63,746

Issue Date FY: 2018 ( Subtotal = $59,038 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Mental Health Research Grants	001	2	6/15/2018	NON-COMPETING CONTINUATION	$1,972
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Mental Health Research Grants	003	2	7/12/2018	NON-COMPETING CONTINUATION	$0
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Mental Health Research Grants	000	2	3/16/2018	NON-COMPETING CONTINUATION	$57,066
2018	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Mental Health Research Grants	002	1	6/29/2018	NEW	$0
														Subtotal = $59,038

Issue Date FY: 2017 ( Subtotal = $56,694 )
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Mental Health Research Grants	001	1	3/15/2017	NEW	$0
2017	2017	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	2150 SHATTUCK AVE RM 313	BERKELEY	CA	94704	ALAMEDA	USA	Mental Health Research Grants	000	1	3/15/2017	NEW	$56,694
														Subtotal = $56,694

Grand Total All Awards = $179,134

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Representational code and causal mechanisms of prefrontal regulation of emotion

Award Number: F32MH113347

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/01/2017

PERIOD OF PERFORMANCE END DATE: 04/12/2020

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