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Functional Properties and Directed Connectivity in the Face-Processing Network

Award Number: F32MH093986
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 06/01/2011
PERIOD OF PERFORMANCE END DATE: 05/31/2013

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Functional Properties and Directed Connectivity in the Face-Processing Network - DESCRIPTION (provided by applicant): This is an application for a National Research Service Award (F32). The candidate for this award is Andrew D. Engell, a postdoctoral associate in the laboratory of Dr. Gregory McCarthy at Yale University. The candidate will continue his postdoctoral training with Dr. McCarthy. The candidate proposes to further his training in neuroscience methods, particularly directed connectivity analysis, via a series of multimodal experiments to study the properties of the brain's face-processing network. Face perception is a highly developed visual skill that is critical for successful social interaction and which is dysfunctional in neurodevelopmental disorders such as autism, and psychiatric disorders such as schizophrenia. Elucidating the properties of this network may lead to a deeper understanding of these disorders and advance strategies for treatment. The candidate proposes three specific aims. In the first aim, the candidate will investigate the latency and source of the brain's initial face-specific response. In the second aim, the candidate will investigate the functional differences and flow of information between a subset of the brain's face processing regions. In the third aim, the candidate will investigate the access of semantic information regarding faces in focal regions of cortex. The candidate proposes to achieve these aims using subdural electroencephalography, cortical stimulation, and functional magnetic resonance imaging. The functional relationship between focal brain regions will be investigated using sophisticated connectivity analysis techniques. Training in the theoretical basis and practical application of these techniques is a core component of the candidate's development as he prepares for an independent research career. PUBLIC HEALTH RELEVANCE: Debilitating deficits in social processing is a core symptom of many psychiatric and neurodevelopmental disorders as diverse as schizophrenia, Williams syndrome, social anxiety disorders, and autistic spectrum disorders. My focus in this training proposal is on investigating the functional properties and connectivity between components of the face-processing network, an essential component of social processing. Understanding the nature of information transactions among the nodes of this network should deepen our insights into the aforementioned clinical disorders and eventually lead to better treatments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$340 )
2017	2012	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Mental Health National Research Service Awards for Research Training	000	2	5/15/2017	NON-COMPETING CONTINUATION	-$340
														Subtotal = -$340

Issue Date FY: 2012 ( Subtotal = $55,670 )
2012	2012	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Mental Health National Research Service Awards for Research Training	000	2	5/9/2012	NON-COMPETING CONTINUATION	$55,670
														Subtotal = $55,670

Issue Date FY: 2011 ( Subtotal = $53,042 )
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Mental Health National Research Service Awards for Research Training	002	1	5/10/2011	NEW	$888
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Mental Health National Research Service Awards for Research Training	001	1	3/4/2011	NEW	$0
2011	2011	YALE UNIVERSITY	PO BOX 208250	NEW HAVEN	CT	06520	SOUTH CENTRAL CT	USA	Mental Health National Research Service Awards for Research Training	000	1	3/4/2011	NEW	$52,154
														Subtotal = $53,042

Grand Total All Awards = $108,372

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Functional Properties and Directed Connectivity in the Face-Processing Network

Award Number: F32MH093986

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 06/01/2011

PERIOD OF PERFORMANCE END DATE: 05/31/2013

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