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The maintenance of fear memories in the amygdala

Award Number: F32MH090700
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/10/2010
PERIOD OF PERFORMANCE END DATE: 03/09/2013

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The maintenance of fear memories in the amygdala - DESCRIPTION (provided by applicant): Pavlovian fear conditioning has proved to be a useful model for the study of the cellular mechanisms of fear learning and memory. Considerable progress has been made in understanding the neural mechanisms that support this form of learning, but very little is known about how fear memories persist in the face of protein turnover. The amygdala is thought to be critical to the acquisition and storage of fear memory, but how this occurs at the cellular level has yet to have been fully answered. Recent studies suggest that protein kinase M zeta (PKM6) becomes persistently active following learning and may support synaptic activity underlying the maintenance of long-term memories. The work in this proposal is designed to explore several questions about how fear memories are maintained in the amygdala. We will test if the deficits in memory following PKM6 inhibition are permanent and if amygdala-dependent fear memories rely on PKM6 activity regardless of the age of the memory. We will also test the hypothesis that the maintenance of fear memory in the amygdala is supported by the trafficking of GluR2 containing 1-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors, which is thought to be controlled by PKM6. Finally, we will use lentiviral vectors to determine if neurons that are involved in the initial acquisition of fear memory are the same cells that use PKM6 to maintain the memory. The long-term goal of the work in this proposal is to reach a better understanding of the fundamental issue of how memories are stored in the brain. The work in this proposal is potentially very useful in coming to a full understanding of how various organic amnesias and psychopathologies develop and persist.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$319 )
2017	2012	EMORY UNIVERSITY	1599 CLIFTON RD.	ATLANTA	GA	30322	DEKALB	USA	Mental Health National Research Service Awards for Research Training	000	3	8/7/2017	NON-COMPETING CONTINUATION	-$319
														Subtotal = -$319

Issue Date FY: 2012 ( Subtotal = $53,942 )
2012	2012	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Mental Health National Research Service Awards for Research Training	000	3	3/1/2012	NON-COMPETING CONTINUATION	$53,942
														Subtotal = $53,942

Issue Date FY: 2011 ( Subtotal = $51,326 )
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Mental Health National Research Service Awards for Research Training	001	2	5/9/2011	NON-COMPETING CONTINUATION	$852
2011	2011	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Mental Health National Research Service Awards for Research Training	000	2	2/9/2011	NON-COMPETING CONTINUATION	$50,474
														Subtotal = $51,326

Issue Date FY: 2010 ( Subtotal = $48,086 )
2010	2010	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Mental Health National Research Service Awards for Research Training	000	1	3/10/2010	NEW	$48,086
2010	2010	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Mental Health National Research Service Awards for Research Training	001	1	3/17/2010	NEW	$0
2010	2010	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Mental Health National Research Service Awards for Research Training	002	1	3/17/2010	NEW	$0
														Subtotal = $48,086

Grand Total All Awards = $153,035

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The maintenance of fear memories in the amygdala

Award Number: F32MH090700

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/10/2010

PERIOD OF PERFORMANCE END DATE: 03/09/2013

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