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The role of octopamine receptor-expressing neurons in aggression.

Award Number: F32MH086202
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/01/2009
PERIOD OF PERFORMANCE END DATE: 11/30/2012

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The role of octopamine receptor-expressing neurons in aggression. - DESCRIPTION (provided by applicant): SPACE PROVIDED. Research Summary: The major goal of this research proposal is to understand the logic that governs how neural circuits give rise to complex behaviors. I have chosen to focus on aggression, a nearly universal animal behavior that is important for survival and reproduction. The biogenic amine octopamine (OA), and its vertebrate counterpart noradrenalin, play important roles in aggression, as well as a variety of other social behaviors. However, the neural circuits on which these molecules act to regulate different social behaviors have not been well characterized. The aim of this proposal is to characterize the circuits that mediate the effects of OA on aggressive behavior in the genetically tractable organism Drosophila melanogaster. As an inroad to this problem, I will use genetic tools to alter neuronal activity of octopamine receptor-expressing neurons in vivo in order to answer the following questions: How does the activity of neurons expressing octopamine receptor 2 (Oa2) influence aggressive behaviors? What are the specific subpopulations of Oa2 neurons that are responsible for aggression and do different populations control various aspects of aggressive behavior? How do these Oa2 neuronal circuits function to mediate aggression and what are the neural pathways that they modulate? I will address these questions with the following specific aims: Aim 1- Loss-of-function and gain-of-function manipulations of octopamine receptor signaling. Aim 2 - Identification and characterization of octopamine receptor neuronal subsets. Aim 3 - Characterization of the projections of individual Oa2 neurons and their post-synaptic targets. Relevance to public health: In humans, aggression that is unchecked, persistent, or expressed out of context has profound negative impacts on society. Aberrant aggressive behavior is also associated with numerous prevalent psychiatric disorders such as depression, post-traumatic stress disorder and alcohol addiction. Investigating aggressive behavior in a genetically tractable model organism will increase our understanding of the basic neural-circuit mechanisms used by the nervous system to control complex behavioral states, such as aggression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$1 )
2017	2012	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health National Research Service Awards for Research Training	000	3	5/15/2017	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2012 ( Subtotal = $53,942 )
2012	2012	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health National Research Service Awards for Research Training	001	3	3/9/2012	NON-COMPETING CONTINUATION	$900
2012	2012	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health National Research Service Awards for Research Training	000	3	11/18/2011	NON-COMPETING CONTINUATION	$53,042
														Subtotal = $53,942

Issue Date FY: 2011 ( Subtotal = $51,326 )
2011	2011	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health National Research Service Awards for Research Training	000	2	11/16/2010	NON-COMPETING CONTINUATION	$50,474
2011	2011	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health National Research Service Awards for Research Training	001	2	5/2/2011	NON-COMPETING CONTINUATION	$852
														Subtotal = $51,326

Issue Date FY: 2009 ( Subtotal = $47,210 )
2009	2009	CALIFORNIA INSTITUTE OF TECHNOLOGY	1200 E CALIFORNIA BLVD	PASADENA	CA	91125	LOS ANGELES	USA	Mental Health National Research Service Awards for Research Training	000	1	6/9/2009	NEW	$47,210
														Subtotal = $47,210

Grand Total All Awards = $152,477

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The role of octopamine receptor-expressing neurons in aggression.

Award Number: F32MH086202

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/01/2009

PERIOD OF PERFORMANCE END DATE: 11/30/2012

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