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The importance of Lysyl Oxidase in Atherosclerosis

Award Number: F32HL158216
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 02/01/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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The importance of Lysyl Oxidase in Atherosclerosis - Abstract This F32 fellowship award aims to facilitate the training and career transition of Dr. Filipe Fernandes Stoyell- Conti, Ph.D., an outstanding minority candidate, in vascular biology and atherosclerosis. Specifically, the grant offers to Dr. Fernandes Stoyell-Conti the possibility of improving his hands-on skills in the laboratory, strengthening his critical thinking and advancing his knowledge in bioinformatics and vascular biology. He will receive training while investigating the role of lysyl oxidase (LOX), a copper-dependent amine oxidase, in smooth muscle cells (SMCs) biology and atherosclerosis. Dr. Fernandes Stoyell-Conti research hypothesis is that LOX facilitates SMC cell migration, inflammation, and foam cell formation during atherogenesis. In three specific aims, he will: 1) investigate whether inactivation of LOX in SMCs compromises in vivo phenotypic switch of SMC, 2) demonstrate that expression of LOX in SMC increases atherosclerosis in hyperlipidemic mice, and 3) examine the molecular mechanisms by which LOX changes gene expression in SMCs. He will combine state of the art animal models, transcriptomics (RNA-seq) and molecular biology to demonstrate that LOX can “turn off/on” gene transcription in SMCs to make them more atherogenic. Together, these studies will advance his knowledge about LOX's role in atherosclerosis and facilitate his transition towards independence as principal investigator in the field of vascular biology and cardiovascular disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $89,488 )
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	3	2/5/2024	NON-COMPETING CONTINUATION	$83,304
2024	2024	UNIVERSITY OF MIAMI	1320 S DIXIE HWY STE 1200	CORAL GABLES	FL	33146	MIAMI-DADE	USA	Cardiovascular Diseases Research	001	3	8/29/2024	NON-COMPETING CONTINUATION	$6,184
														Subtotal = $89,488

Issue Date FY: 2023 ( Subtotal = $80,928 )
2023	2023	UNIVERSITY OF MIAMI	1400 NW 10TH AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	2	3/10/2023	NON-COMPETING CONTINUATION	$80,928
														Subtotal = $80,928

Issue Date FY: 2021 ( Subtotal = $75,130 )
2021	2021	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	1	7/27/2021	NEW	$75,130
2021	2021	UNIVERSITY OF MIAMI	1600 NW 10 AVE	MIAMI	FL	33136	MIAMI-DADE	USA	Cardiovascular Diseases Research	001	1	7/27/2021	NEW	$0
														Subtotal = $75,130

Grand Total All Awards = $245,546

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The importance of Lysyl Oxidase in Atherosclerosis

Award Number: F32HL158216

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 02/01/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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