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Hybrid-FES Exercise to Attenuate Increased Central Adiposity andImprove Glucoregulatory Control in Acute SCI

Award Number: F32HL156675
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/01/2022
PERIOD OF PERFORMANCE END DATE: 07/07/2023

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Hybrid-FES Exercise to Attenuate Increased Central Adiposity andImprove Glucoregulatory Control in Acute SCI - ABSTRACT / PROJECT SUMMARY This postdoctoral F32 Kirschstein NRSA proposes unique research and includes a comprehensive training plan in the study of functional electrical stimulation row training (FESRT) as a rehabilitation technique in individuals with spinal cord injuries (SCI). Individuals with spinal cord injuries have a greater morbidity and mortality risk from cardiovascular disease (CVD) than able-bodied individuals. The increased risk could be due, in part, to increased fat mass or dysregulated adipokine production leading to an impaired glucoregulatory control as a result of muscle atrophy and increased sedentary activity. Functional electrical stimulation (FES) exercise is increasingly being used in the acute and long-term rehabilitation of individuals with spinal cord injuries. Our lab uses this technique to induce leg extension and flexion in combination with voluntary upper body movements allowing for whole body rowing (FESRT). This exercise, incorporated into a 6-month training regimen, has been shown to increase aerobic fitness, attenuate gains in fat and loss of paralyzed muscle mass, and control blood glucose; hence, decreasing risk for CVD. However, there is currently a lack of information concerning retention of exercise training adaptations in those with SCI. Therefore, we propose a retrospective study to analyze body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in a group of individuals with SCI (n=31) who participated in 6 months of FESRT and either continued training (n=15) or returned to standard of care (n=16) (AIM 1). Additionally, these beneficial adaptations to FESRT may be proportional to exercise training intensity. Pulmonary limitations in SCI likely limit the attainment of sustainably vigorous FESRT exercise intensities. Therefore, we plan on studying changes in body composition, adipose tissue adipokine production, serum adipokine concentrations, and glucoregulatory control in relation to exercise training intensity in a prospective study that incorporates mechanical (non-invasive ventilation) and pharmaceutical (serotonin receptor agonist) ergogenic aids to increase ventilatory capacity (AIM 2). The ultimate purpose of this research is to optimize exercise training protocols for a population that both needs and seeks a broad range of benefits that exercise can confer. This F32 postdoctoral fellowship research and training plan will help develop and optimize rehabilitation strategies in individuals with spinal cord injuries and prepare me to advance as an independent researcher.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2023	THE SPAULDING REHABILITATION HOSPITAL CORPORATION	300 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Cardiovascular Diseases Research	000	2	5/22/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $29,623 )
2023	2023	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Cardiovascular Diseases Research	001	2	7/25/2023	NON-COMPETING CONTINUATION	-$44,669
2023	2023	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Cardiovascular Diseases Research	000	2	3/13/2023	NON-COMPETING CONTINUATION	$74,292
														Subtotal = $29,623

Issue Date FY: 2022 ( Subtotal = $70,082 )
2022	2022	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Cardiovascular Diseases Research	002	1	7/2/2022	NEW	$0
2022	2022	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Cardiovascular Diseases Research	001	1	7/2/2022	NEW	$1,192
2022	2022	SPAULDING REHABILITATION HOSPITAL CORPORATION, THE	300 FIRST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Cardiovascular Diseases Research	000	1	2/18/2022	NEW	$68,890
														Subtotal = $70,082

Grand Total All Awards = $99,705

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Hybrid-FES Exercise to Attenuate Increased Central Adiposity andImprove Glucoregulatory Control in Acute SCI

Award Number: F32HL156675

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/01/2022

PERIOD OF PERFORMANCE END DATE: 07/07/2023

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