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INFLUENCE OF BLOOD PRESSURE ON PAD DISTRIBUTION

Award Number: F32HL083597
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 06/01/2006
PERIOD OF PERFORMANCE END DATE: 11/30/2007

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INFLUENCE OF BLOOD PRESSURE ON PAD DISTRIBUTION - DESCRIPTION (provided by applicant): Endothelial dysfunction is thought to play a key role in the pathogenesis of peripheral arterial disease (PAD). Interestingly, PAD is much more prevalent in the lower extremities than the upper extremities. It has been hypothesized that elevated blood pressure in the lower extremities during upright posture may account for these regional differences in the distribution of PAD. This is supported by evidence of a link between elevated blood pressure and atherosclerosis. Accordingly, the primary aim of the present proposal is to test two hypotheses: 1) Endothelium-dependent relaxation is attenuated with elevated blood pressure; and 2) Atherosclerosis is accentuated with elevated blood pressure. To address these aims, a model of aortic coarctation will be utilized to induce a blood pressure gradient similar but opposite to that of an upright human. Endothelium-dependent and -independent relaxation will be measured in the brachial and femoral arteries of coarctated and control swine. In addition, eNOS protein content will be assessed by immunoblots and immunohistochemistry techniques in the brachial and femoral arteries of coarctated and control animals. Lastly, atherosclerotic lesions will be assessed using histological analysis in conjuction with the Stary scale.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $17,432 )
2007	2007	UNIVERSITY OF MISSOURI, KANSAS CITY	5100 ROCKHILL ROAD	KANSAS CITY	MO	64110	JACKSON	USA	Cardiovascular Diseases Research	000	2	5/31/2007	NON-COMPETING CONTINUATION	$17,432
														Subtotal = $17,432

Issue Date FY: 2006 ( Subtotal = $45,976 )
2006	2006	UNIVERSITY OF MISSOURI, KANSAS CITY	5100 ROCKHILL ROAD	KANSAS CITY	MO	64110	JACKSON	USA	Cardiovascular Diseases Research	000	1	6/1/2006	NEW	$45,976
														Subtotal = $45,976

Grand Total All Awards = $63,408

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INFLUENCE OF BLOOD PRESSURE ON PAD DISTRIBUTION

Award Number: F32HL083597

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 06/01/2006

PERIOD OF PERFORMANCE END DATE: 11/30/2007

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