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Advancing Pharmacogenetics in Montana Through a Landscape Assessment and Implementation

Award Number: F32HG013895
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 11/02/2024
PERIOD OF PERFORMANCE END DATE: 10/31/2027

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Advancing Pharmacogenetics in Montana Through a Landscape Assessment and Implementation - Pharmacogenetics (PGx) can greatly impact prescribing practices by ensuring a personalized approach to drug treatment, however, access to PGx is not available for everyone. The primary objective of this research is to evaluate the clinical impact and utility of PGx implementation in Montana, with a specific focus on implementation for rural communities. With a goal to ensure dissemination of innovations like PGx, this project aims to assess the prescribing patterns of PGx medications in rural settings (Aim 1) and gather insights into the clinical utility and uptake of PGx testing among health care providers (Aim 2). We will also conduct biostatistical and geospatial analysis of the prescribing patterns of PGx medications in rural areas and identify the optimal therapeutic areas and geographic locations for targeted implementation. We will complete a comprehensive assessment of the clinical utility and uptake of PGx implementation among health care providers in Montana through qualitative surveys. Data will include provider demographics and practice setting location, frequency of PGx consultations, and assessment of prescribing changes based on PGx results (e.g., dose adjustment, medication selection, discontinuation). The results obtained from this project will contribute to advancing PGx implementation strategies in Montana, and will serve as a valuable foundation for future research and implementation efforts in areas across the US. We will oversee the entire research project including survey development and distribution, health data collection, biostatistical and geospatial analysis, and complete interpretation of results. We plan to complete the outlined proposal with the support and supervision of investigators in the L.S. Skaggs Institute for Health Innovation and the Center for Population Health Research at the University of Montana. The postdoctoral fellow will receive training to promote her growth as an independent investigator, completing rigorous training in biostatistical and geospatial analysis, data visualization, and programming. The fellow will also attend and submit abstracts to scientific meetings, supervise research students, and provide instruction for pharmacy and graduate students. The data gathered in this proposal will be used by the postdoctoral fellow to secure extramural research funding to establish a career as an independent investigator in the fields of PGx, implementation science, and health outcomes research. Insights derived from our research will contribute to integrating evidence-based gene-guided prescribing into standard health practices, thereby fostering a paradigm shift towards personalized treatment approaches.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $80,646 )
2026	2026	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Human Genome Research	000	2	12/23/2025	NON-COMPETING CONTINUATION	$80,646
														Subtotal = $80,646

Issue Date FY: 2024 ( Subtotal = $78,954 )
2024	2024	UNIVERSITY OF MONTANA	32 CAMPUS DR	MISSOULA	MT	59812	MISSOULA	USA	Human Genome Research	000	1	8/30/2024	NEW	$78,954
														Subtotal = $78,954

Grand Total All Awards = $159,600

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Advancing Pharmacogenetics in Montana Through a Landscape Assessment and Implementation

Award Number: F32HG013895

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 11/02/2024

PERIOD OF PERFORMANCE END DATE: 10/31/2027

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