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THE USE OF RECOMBINING GENETIC MARKERS FOR DEMOGRAPHIC INFERENCE

Award Number: F32HG004182
ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 11/16/2006
PERIOD OF PERFORMANCE END DATE: 12/31/2007

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THE USE OF RECOMBINING GENETIC MARKERS FOR DEMOGRAPHIC INFERENCE - DESCRIPTION (provided by applicant): The proposed research concerns the inference of historical patterns of migration. Traditional population genetic models of migration assume that populations have been exchanging migrants at a constant rate over long periods of time. For many species, however, this assumption may not be appropriate. Therefore, the development of a computational method to test for recent changes in migration rate and to estimate the relevant demographic parameters is proposed. While most methods of demographic inference assume that all of the genetic markers being studied are independent (unlinked), this approach will take advantage of the patterns of linkage along a recombining chromosome. By considering this linkage information (specifically, the lengths of DNA segments that inferred to have migrant origin), one can go beyond estimating how much migration has occurred between two populations, and say something about when, historically, this migration occurred. During the first phase of this project, the effect of various population histories on the length distribution of migrant DNA segments will be investigated, making use of an existing simulation program (ms) and inference method (structure 2.0). Next, the new inference method described above will be developed, using Markov chain Monte Carlo methodology in a maximum likelihood or Bayesian framework. Finally, this method will be applied to existing human polymorphism data sets (both SNP and microsatellite) in order to test the null hypothesis that migration among human populations has been constant since their divergence. This analysis will permit the estimation of demographic parameters for admixed human populations, and will therefore aid in the selection of populations for admixture mapping studies of disease association. Relevance to public health: The goal of the proposed research is to test for historical changes in the rate of migration between populations, and to estimate quantities such as the time since a migration rate change and the magnitude of such a change. The computational method developed will have a variety of applications, including the estimation of demographic parameters in human populations with a history of recent admixture (ancestry from multiple sources), such as African-American, Hispanic, Central Asian and Northern African populations. That information will be relevant in assessing the utility of such populations for admixture mapping studies, which aim to identify genetic variants associated with complex diseases that occur at different frequencies in different populations.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2008	UNIVERSITY OF COPENHAGEN	NOERREGADE 10 COPENHAGEN 1017	COPENHAGEN				DNK	Human Genome Research	000	2	8/4/2012	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $48,796 )
2009	2009	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Human Genome Research	000	4	10/29/2008	NON-COMPETING CONTINUATION	$48,796
														Subtotal = $48,796

Issue Date FY: 2008 ( Subtotal = $45,976 )
2008	2008	UNIVERSITY OF CALIFORNIA, REGENTS	481 UNIVERSITY HALL	BERKELEY	CA	94704	ALAMEDA	USA	Human Genome Research	000	3	2/27/2008	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$41,104
2008	2008	UNIVERSITY OF COPENHAGEN	NOERREGADE 10 COPENHAGEN 1017	COPENHAGEN				DNK	Human Genome Research	000	2	1/22/2008	NON-COMPETING CONTINUATION	$4,872
														Subtotal = $45,976

Issue Date FY: 2006 ( Subtotal = $43,996 )
2006	2006	UNIVERSITY OF COPENHAGEN	BLEGDAMSVEJ 3 2200 N	COPENHAGEN		00000		DNK	Human Genome Research	001	1	9/28/2006	NEW	$7,000
2006	2006	UNIVERSITY OF COPENHAGEN	NOERREGADE 10 COPENHAGEN 1017	COPENHAGEN				DNK	Human Genome Research	000	1	9/26/2006	NEW	$36,996
														Subtotal = $43,996

Grand Total All Awards = $138,768

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THE USE OF RECOMBINING GENETIC MARKERS FOR DEMOGRAPHIC INFERENCE

Award Number: F32HG004182

ORGANIZATION: NATIONAL HUMAN GENOME RESEARCH INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 11/16/2006

PERIOD OF PERFORMANCE END DATE: 12/31/2007

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