Official websites use .gov

A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS

A lock ( 🔒 ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Need Help

Invasive trophoblast cell differentiation

Award Number: F32HD116506
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 08/12/2024
PERIOD OF PERFORMANCE END DATE: 08/11/2027

Group Awards By:

View Award Description

Invasive trophoblast cell differentiation - PROJECT SUMMARY In the early stages of human pregnancy, cells from the developing placenta, termed extravillous trophoblast (EVT) cells, must interact with the uterus. In other species including the rat, this special class of trophoblasts are generically termed invasive trophoblast cells. The interaction between invasive trophoblast/EVT cells and the uterus results in the necessary remodeling of spiral arteries to meet the increased demand of blood flow and oxygen during pregnancy. Once remodeled, these arteries will integrate into the uterus to function in transporting nutrients and waste to and from the fetus through the maternal bloodstream. Importantly, differentiation into these specialized trophoblast cell types requires suppression of pathways essential for maintaining the trophoblast cell stem state and activation of the invasive/EVT cell differentiation program. In this project, we investigate roles for the leukemia inhibitory factor (LIF) and signal transducer and activator of transcription 3 (STAT3) pathway in the regulation of invasive/EVT cell development. Roles for LIF/STAT3 regulatory networks in human trophoblast stem cell models are the focus of Specific Aim 1. In Specific Aim 2, we will leverage a Stat3 conditional rat model to investigate STAT3 effects on the development and functionality of the invasive trophoblast cells at the uterine- placental interface. Experimentation includes genome-wide analyses of the transcriptome and the chromatin landscape. Completion of this research project will facilitate the discovery of molecular controllers responsible for regulating invasive/EVT cell lineage as well as create a platform for understanding the pathogenesis of early pregnancy loss. In addition, this proposal will provide the postdoctoral trainee with the mentorship, training, and skills required to become a successful independent investigator dedicated to human fertility research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $79,348 )
2026	2026	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	3	7/15/2026	NON-COMPETING CONTINUATION	$79,348
														Subtotal = $79,348

Issue Date FY: 2025 ( Subtotal = $75,520 )
2025	2025	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	2	7/24/2025	NON-COMPETING CONTINUATION	$75,520
														Subtotal = $75,520

Issue Date FY: 2024 ( Subtotal = $73,828 )
2024	2024	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	000	1	8/12/2024	NEW	$73,828
2024	2024	UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE, INC.	3901 RAINBOW BLVD	KANSAS CITY	KS	66160	WYANDOTTE	USA	Child Health and Human Development Extramural Research	001	1	8/12/2024	NEW	$0
														Subtotal = $73,828

Grand Total All Awards = $228,696

Top

All Categories

About

Search

Reports

Data Submission

Award Information

Invasive trophoblast cell differentiation

Award Number: F32HD116506

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 08/12/2024

PERIOD OF PERFORMANCE END DATE: 08/11/2027

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer