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PERIPLAKIN'S ROLE IN ASSEMBLY OF THE CORNIFIED ENVELOPE

Award Number: F32HD042379
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/22/2003
PERIOD OF PERFORMANCE END DATE: 04/21/2005

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PERIPLAKIN'S ROLE IN ASSEMBLY OF THE CORNIFIED ENVELOPE - DESCRIPTION: (provided by applicant): The creation of the skin barrier between the human body and the environment is carried out by terminally differentiating keratinocytes, which form a structure known as the cornified envelope. The cornified envelope is an insoluble layer of proteins and lipids lining the inner surface of the plasma membrane of keratinocytes in the upper layers of the epidermis. If the cornified envelope is unable to properly form, the consequences for an organism may include an increased susceptibility to infection or lethality due to transepidermal water loss. The cornified envelope appears to be assembled in a regulated fashion, however the precise roles that several of its constituent proteins play in its formation are unknown. The plakin family members periplakin and envoplakin are expressed in terminally differentiating keratinocytes and are thought to form a scaffold on which the cornified envelope is assembled. The role(s) that these proteins play in cornified envelope assembly will be determined by examining the mice doubly deficient in periplakin and envoplakin expression. To further define the mechanism by which periplakin functions, proteins that interact with periplakin will be identified. Additionally, specific amino acids required for proper localization of periplakin will be determined. Finally, putative dominant negative forms of periplakin will be constructed to further determine its role in the epidermis. Overall, the proposed experiments will contribute to knowledge of the mechanism by which the cornified envelope is assembled.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $47,296 )
2004	2004	IMPERIAL CANCER RESEARCH FUND	LINCOLNS INN FIELDS	LONDON		00000		GBR	Child Health and Human Development Extramural Research	001	3	4/9/2004	NON-COMPETING CONTINUATION	$5,500
2004	2004	IMPERIAL CANCER RESEARCH FUND	NihJuly.dat						Child Health and Human Development Extramural Research	000	3	4/8/2004	NON-COMPETING CONTINUATION	$41,796
														Subtotal = $47,296

Issue Date FY: 2003 ( Subtotal = $41,608 )
2003	2003	IMPERIAL CANCER RESEARCH FUND	NihJuly.dat						Child Health and Human Development Extramural Research	000	2	6/6/2003	NON-COMPETING CONTINUATION	$36,108
2003	2003	IMPERIAL CANCER RESEARCH FUND	LINCOLNS INN FIELDS	LONDON		00000		GBR	Child Health and Human Development Extramural Research	001	2	6/13/2003	NON-COMPETING CONTINUATION	$5,500
														Subtotal = $41,608

Issue Date FY: 2002 ( Subtotal = $36,592 )
2002	2002	IMPERIAL CANCER RESEARCH FUND	LINCOLNS INN FIELDS	LONDON		00000		GBR	Child Health and Human Development Extramural Research	001	1	3/25/2002	NEW	$5,500
2002	2002	IMPERIAL CANCER RESEARCH FUND	LINCOLNS INN FIELDS	LONDON		00000		GBR	Child Health and Human Development Extramural Research	000	1	3/22/2002	NEW	$31,092
														Subtotal = $36,592

Grand Total All Awards = $125,496

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PERIPLAKIN'S ROLE IN ASSEMBLY OF THE CORNIFIED ENVELOPE

Award Number: F32HD042379

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/22/2003

PERIOD OF PERFORMANCE END DATE: 04/21/2005

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