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RIP140 REGULATION OF GLUT4 EXPRESSION

Award Number: F32DK070404
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/15/2005
PERIOD OF PERFORMANCE END DATE: 07/14/2008

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RIP140 REGULATION OF GLUT4 EXPRESSION - DESCRIPTION (provided by applicant): Insulin acts on fat and muscle to stimulate the translocation of Glut4 from an intracellular storage compartment to the plasma membrane, where it can remove excess glucose from the blood. The amount of Glut4 expressed in adipose tissue affects glucose tolerance and insulin sensitivity. Thus it is critical that we understand the molecular mechanisms regulating Glut4 expression in adipose tissue. We designed a screen to identify novel regulators of glucose uptake using short-interfering RNA (siRNA)-mediated gene silencing in 3T3-L1 adipocytes. Depletion of the transcriptional corepressor receptor interacting protein 140 (RIP140) enhanced glucose uptake, largely by increasing Glut4 expression. We thus hypothesize that RIP140 acts as a corepressor of Glut4 transcription. The increase in glucose uptake with RIP140 depletion required the presence of the transcription factor C/EBPa, but not the transcription factors PPARg or LXRa. We therefore hypothesize that RIP140 represses Glut4 expression through an interaction with C/EBPa. We propose to test these hypotheses in order to gain an understanding of the role of RIP140 in regulating Glut4 expression in adipocytes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2007 ( Subtotal = $52,048 )
2007	2007	UNIVERSITY OF MASSACHUSETTS	STATE HOUSE ROOM 109	BOSTON	MA	02133	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/15/2007	NON-COMPETING CONTINUATION	$52,048
														Subtotal = $52,048

Issue Date FY: 2006 ( Subtotal = $50,428 )
2006	2006	UNIVERSITY OF MASSACHUSETTS	STATE HOUSE ROOM 109	BOSTON	MA	02133	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	6/19/2006	NON-COMPETING CONTINUATION	$50,428
														Subtotal = $50,428

Issue Date FY: 2005 ( Subtotal = $48,296 )
2005	2005	UNIVERSITY OF MASSACHUSETTS	STATE HOUSE ROOM 109	BOSTON	MA	02133	SUFFOLK	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/14/2005	NEW	$48,296
														Subtotal = $48,296

Grand Total All Awards = $150,772

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RIP140 REGULATION OF GLUT4 EXPRESSION

Award Number: F32DK070404

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/15/2005

PERIOD OF PERFORMANCE END DATE: 07/14/2008

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