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Diagnose and Differentiate Dental Pain from Stress Using a Wearable Electrodermal Activity Device

Award Number: F32DE033566
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 12/01/2024
PERIOD OF PERFORMANCE END DATE: 11/30/2027

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Diagnose and Differentiate Dental Pain from Stress Using a Wearable Electrodermal Activity Device - Project Summary We propose to diagnose and differentiate dental pain from stress using a wearable electrodermal activity (EDA) device. Dental caries is one of the major causes of endodontic infection in the pulp or soft tissues of the tooth, causing hypersensitivity, severe pain, and even death. It is estimated that at least 2 billion adults and 520 million children suffer from dental caries worldwide. EDA has shown the capability to objectively assess dental pain since it measures the electrical conductance of the skin due to innervation of the sympathetic nervous system (SNS). However, EDA has two fundamental issues. First, stress can also elicit an EDA response via the SNS, and stress commonly presents in dental clinics due to pain anticipation and previous experience. Second, EDA analysis relies on knowing the onset and end timepoints of a stimulus and when the subject feels pain on the affected teeth, which is difficult to obtain from patients with communication issues. Skin nerve activity (SKNA), recorded via ECG at high sampling rates (>4 kHz), has been shown to represent the dynamics of the SNS with precise start and end times of nerve firing, which can be used to align events in the EDA signal for subsequent EDA analysis. Therefore, we propose to use the skin nerve activity (SKNA) signal, derived from the ECG, to precisely locate the onset and end of noxious stimuli. We will also apply and validate a machine learning model to detect and differentiate EDA segments affected by stress from pain during pulpal diagnosis. As both pain and stress increase amplitudes of EDA signals, albeit less with the latter, it is crucial to develop a quantitative approach to differentiate stress from pain in EDA signals. Therefore, we will investigate SKNA and EDA signals from datasets collected during dental examination to separate stress from pain response so that more accurate assessment of pain due to noxious stimuli during dental examination can be made. Our approach combining SKNA and EDA will allow autonomous and more accurate segmentation of the data that are specific to pain and stress, which will be especially useful for patients with communication issues, and ultimately will lead to more accurate assessment of pain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $84,024 )
2026	2026	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Oral Diseases and Disorders Research	000	2	12/9/2025	NON-COMPETING CONTINUATION	$84,024
														Subtotal = $84,024

Issue Date FY: 2025 ( Subtotal = $3,000 )
2025	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Oral Diseases and Disorders Research	001	1	12/19/2024	NEW	$0
2025	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Oral Diseases and Disorders Research	000	1	12/19/2024	NEW	$3,000
														Subtotal = $3,000

Issue Date FY: 2024 ( Subtotal = $77,556 )
2024	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Oral Diseases and Disorders Research	000	1	8/12/2024	NEW	$77,556
														Subtotal = $77,556

Grand Total All Awards = $164,580

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Diagnose and Differentiate Dental Pain from Stress Using a Wearable Electrodermal Activity Device

Award Number: F32DE033566

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 12/01/2024

PERIOD OF PERFORMANCE END DATE: 11/30/2027

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