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Identification and characterization of second-order taste neurons in Drosophila

Award Number: F32DC018225
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 01/15/2022
PERIOD OF PERFORMANCE END DATE: 09/14/2022

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Identification and characterization of second-order taste neurons in Drosophila - A major question in neuroscience is how animals translate sensory input into motor output. A particularly good system to address this question is the Drosophila gustatory (taste) system, since both the primary sugar-sensing neurons as well as the motor neurons that elicit feeding are well characterized. When a hungry fly encounters appetizing food, it extends its proboscis and begins feeding. As both the primary sensory inputs and motor outputs are located in close proximity to each other in the subesophageal zone (SEZ) of the Drosophila brain, local circuits in the SEZ likely govern feeding decisions. This proposal intends to identify second-order taste neurons that may bridge sensory inputs and motor outputs. Activation of 7 different candidate second-order taste neurons, similar to activation of the primary sugar sensing neurons, is sufficient to generate feeding behavior. Thus, candidate neurons identified thus far may be involved in the pathway from sensory input to motor output. To analyze the role that second- order taste neurons play in feeding, Aim 1 will determine the anatomical connectivity between first-order taste neurons and candidate second-order neurons, Aim 2 will determine the stimuli that second-order neurons respond to, and Aim 3 will determine the behaviors that second- order neurons mediate. By identifying and characterizing second-order taste neurons, this proposal will build the foundation for understanding how basic sensory information is integrated with internal cues, such as hunger, into behaviors like feeding. An understanding of feeding decisions in insects may provide insights into how to prevent the spread of diseases such as malaria that depend on an insect vector. Furthermore, because flies respond to similar cues as mammals, such as appetizing sugar substances and bitter toxins, understanding the circuits that underlie feeding may shed light into human feeding related disorders such as obesity and diabetes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 201	BERKELEY	CA	94710	ALAMEDA	USA	Research Related to Deafness and Communication Disorders	000	3	7/21/2023	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $2,500 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Research Related to Deafness and Communication Disorders	000	3	10/28/2021	SUPPLEMENT FOR EXPANSION	$2,500
														Subtotal = $2,500

Issue Date FY: 2021 ( Subtotal = $66,390 )
2021	2021	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Research Related to Deafness and Communication Disorders	000	3	8/19/2021	NON-COMPETING CONTINUATION	$66,390
														Subtotal = $66,390

Issue Date FY: 2020 ( Subtotal = $64,926 )
2020	2020	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Research Related to Deafness and Communication Disorders	000	2	8/21/2020	NON-COMPETING CONTINUATION	$64,926
														Subtotal = $64,926

Issue Date FY: 2019 ( Subtotal = $60,854 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Research Related to Deafness and Communication Disorders	001	1	3/25/2019	NEW	$0
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE	1608 4TH ST STE 220	BERKELEY	CA	94710	ALAMEDA	USA	Research Related to Deafness and Communication Disorders	000	1	3/25/2019	NEW	$60,854
														Subtotal = $60,854

Grand Total All Awards = $194,670

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Identification and characterization of second-order taste neurons in Drosophila

Award Number: F32DC018225

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 01/15/2022

PERIOD OF PERFORMANCE END DATE: 09/14/2022

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