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Improving the Measurement of Brain-Behavior Associations in Adolescence

Award Number: F32DA055334
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Improving the Measurement of Brain-Behavior Associations in Adolescence - Project Abstract The effect of analytic flexibility on brain-behavior relationships and predictive models of adolescent socioemotional processing is not well understood. The Maturational Imbalance (or Dual System) Model often lacks reliability and generalizability. Existing work has predominately focused on single task-designs and small samples (median < 50) concentrating on brain-behavior associations using disparate operationalizations of reward and affective processing. The proposed research will integrate three developmental functional magnetic resonance imaging (fMRI) samples (N ~ 105; N ~ 180; N ~ 7,000), with analogous reward and affective paradigms, to investigate key issues related to reproducibility and generalizability: (a) the influence of analytic flexibility on brain-behavior associations and convergence and predictive validity in contrasts within/between task domains; and (b) uncovering task-based fMRI (t-fMRI) brain features (latent neural characteristics) that can serve as the basis for robust brain-behavior prediction models across multiple samples. It is hypothesized that t-fMRI contrasts can be separated across a multidimensional plane of attention and valence, which elicits neural responses leading to approach or avoidance. However, how researchers operationalize positive and negative valence in t-fMRI often varies, and this variability in the decision-making process may influence the underlying neural effects. Aim 1a will examine how brain-behavior associations in a given task change based on analytic decisions relating to fitting general linear models (GLM), contrasts and neural regions. Then, Aim 1b will consider whether changes in brain-behavior associations (as a functional of analytic flexibility) are reflected in changes in construct validity of approach and avoidance within- and between-task domains, such as reward and affective processing. Conversely, traditional univariate GLM approaches show mounting issues in test-retest reliability and express associations that may not support generalizable prediction of behavioral phenotypes. However, the neurodevelopmental literature has proposed that multivariate analyses that leverage dimensionality reduction and machine learning can provide informative brain-behavior prediction models. To test this hypothesis, in Aim 2, dimensionality reduction will be used in a large adolescent t-fMRI sample to generate brain-behavior prediction models and compared across a reward and affective task to consider the influence of constructs. Aim 3 will focus on the dissemination of code and fMRI statistical maps. The fellowship will support the applicant's growth in becoming an independent researcher and leader in the neurodevelopmental neuroscience by providing training in: combining t-fMRI datasets, evaluating the effect of analytic flexibility in fMRI and impact on construct validity, applying dimensionality reduction in neurodevelopmental samples to produce brain-behavior prediction models. This training will support the applicant's long-term goals of understanding of neural mechanisms in adolescent substance use and improving our understanding of traditional and non-traditional measurement models.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $76,384 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Drug Use and Addiction Research Programs	000	3	6/14/2024	NON-COMPETING CONTINUATION	$76,384
														Subtotal = $76,384

Issue Date FY: 2023 ( Subtotal = $71,180 )
2023	2023	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Drug Use and Addiction Research Programs	000	2	5/18/2023	NON-COMPETING CONTINUATION	$71,180
														Subtotal = $71,180

Issue Date FY: 2022 ( Subtotal = $69,490 )
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Drug Use and Addiction Research Programs	000	1	6/8/2022	NEW	$69,490
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Drug Use and Addiction Research Programs	002	1	6/8/2022	NEW	$0
2022	2022	LELAND STANFORD JUNIOR UNIVERSITY, THE	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Drug Use and Addiction Research Programs	001	1	6/8/2022	NEW	$0
														Subtotal = $69,490

Grand Total All Awards = $217,054

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Improving the Measurement of Brain-Behavior Associations in Adolescence

Award Number: F32DA055334

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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