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Dopamine function in reward-driven decision making

Award Number: F32DA036979
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/01/2015
PERIOD OF PERFORMANCE END DATE: 02/28/2018

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Dopamine function in reward-driven decision making - DESCRIPTION (provided by applicant): Addiction is costly to both the individuals and society, and relapses after current treatment methods are common. To significantly affect the prevalence of addiction and other reward-related disorders, it is imperative to understand the neural mechanisms underlying reward regulation. Dopamine deficits are well documented in patients with reward disorders. Dopamine is hypothesized to affect reward regulation by modulating response choice and the vigor with which the response is executed. However, no study to date has measured endogenous dopamine function in vivo in humans to directly examine how the dopamine system mediates response choice and response vigor. This research plan will use positron emission tomography (PET) to assess endogenous dopamine function and functional magnetic resonance imaging (fMRI) to identify the shared and differential neural correlates of response choice and response vigor. In addition, personality traits associated with addiction will be assessed. The goal of all aims is to develop a multilevel understanding of reward regulation through endogenous dopamine function, brain networks seen with fMRI, personality traits, response choice, and response vigor. The applicant's long-term goals are to identify deviations in the dopamine system leading to reward disorders and to develop effective interventions targeting specific aspects of dopamine function. This fellowship will help the applicant build an independent research program that leads to a productive career as an investigator of reward-driven behavior.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$4 )
2021	2017	VANDERBILT UNIVERSITY, THE	2301 VANDERBILT PL	NASHVILLE	TN	37235	DAVIDSON	USA	Drug Use and Addiction Research Programs	000	3	12/31/2020	NON-COMPETING CONTINUATION	-$4
														Subtotal = -$4

Issue Date FY: 2017 ( Subtotal = $60,990 )
2017	2017	VANDERBILT UNIVERSITY, THE	211 KIRKLAND HALL	NASHVILLE	TN	37240	DAVIDSON	USA	Drug Use and Addiction Research Programs	000	3	2/13/2017	NON-COMPETING CONTINUATION	$60,990
														Subtotal = $60,990

Issue Date FY: 2016 ( Subtotal = $58,002 )
2016	2016	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Drug Use and Addiction Research Programs	001	2	1/27/2016	NON-COMPETING CONTINUATION	$58,002
2016	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Drug Use and Addiction Research Programs	000	1	1/6/2016	NEW	$0
														Subtotal = $58,002

Issue Date FY: 2015 ( Subtotal = $54,194 )
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Drug Use and Addiction Research Programs	001	1	2/18/2015	NEW	$0
2015	2015	VANDERBILT UNIVERSITY HOSPITAL, CHILDREN'S REHAB UNIT	1161 21ST AVENUE SOUTH	NASHVILLE	TN	37232	DAVIDSON	USA	Drug Use and Addiction Research Programs	000	1	2/18/2015	NEW	$54,194
														Subtotal = $54,194

Grand Total All Awards = $173,182

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Dopamine function in reward-driven decision making

Award Number: F32DA036979

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/01/2015

PERIOD OF PERFORMANCE END DATE: 02/28/2018

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