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Exacerbation of Coxsackievirus B3-Induced Pancreatitis by NOD2 Autoregulation Across the Gut-Pancreas Axis

Award Number: F32AI197527
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 04/01/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2029

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Exacerbation of Coxsackievirus B3-Induced Pancreatitis by NOD2 Autoregulation Across the Gut-Pancreas Axis - PROJECT SUMMARY Coxsackieviruses are single stranded RNA viruses in the enterovirus genus that cause a wide variety of disease symptoms in humans, especially in young children. The CDC reports that in the United States, there are approximately 10-15 million non-polio enterovirus infections each year, most of which are caused by coxsackieviruses. Despite this high case number, there are currently no specific treatments available for coxsackievirus infections. Coxsackievirus B3 (CVB3) is a common serovar that colonizes humans via the fecal- oral route and disseminates to other tissues such as the heart, pancreas, and central nervous system. In the pancreas, CVB3 infection can cause viral pancreatitis, a life-threatening inflammatory disease that often leads to complications like pancreatic cancer, organ failure, and type 1 diabetes. Furthermore, CVB3-induced pancreatitis is thought to precede CVB3-induced myocarditis, another lethal inflammatory disease caused by viral colonization of heart muscle tissue. While Coxsackievirus-induced myocarditis has received significant research attention, very little is still known about Coxsackievirus-induced pancreatitis. Recently, it was demonstrated that the cytoplasmic pattern recognition receptor NOD2, which induces innate immune signaling in response to infection and damage patterns in the cell, exacerbates pathogenesis and disease in CVB3 infected mice. This is surprising since NOD2 is host-protective during many viral and bacterial infections. Using a similar mouse model of CVB3 infection, we observed that inflammatory cytokine expression in the pancreas was significantly lower when NOD2 is not expressed in the intestinal epithelium, suggesting that intestinal NOD2 promotes inflammation in the pancreas during CVB3 infection. NOD2 is known to upregulate intestinal barrier function and upregulate mitophagy in response to the bacterial peptidoglycan fragment muramyl dipeptide (MDP). Additionally, mitophagy can downregulate inflammation due to a reduction in mitochondrial reactive oxygen species (ROS) production, which in turn downregulates NLRP3 inflammasome activation. If intestinal NOD2-mediated barrier function sufficiently inhibits translocation of bacteria to the pancreas during CVB3 infection, it may promote pancreatic NLRP3 inflammasome activation by limiting MDP/NOD2-mediated mitophagy. Since excessive host inflammatory response contributes significantly to disease severity during viral pancreatitis, the relationship between inflammasome activation and NOD2 autoregulation across the gut- pancreas axis may play an important role in disease outcome during CVB3 infection. These questions will be investigated with the following aims: Aim 1: Determine whether intestinal NOD2 barrier function inhibits host-protective activation of pancreatic NOD2 during CVB3-induced pancreatitis; and Aim 2: Determine if MDP-dependent activation of NOD2 in pancreas cells inhibits ROS-dependent inflammasome activation by upregulating mitophagy. These studies will elucidate the mechanisms of NOD2 signaling in both the intestinal epithelium and pancreas that promote inflammatory disease during viral pancreatitis.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $76,300 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Allergy and Infectious Diseases Research	002	1	4/13/2026	NEW	$0
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Allergy and Infectious Diseases Research	001	1	4/13/2026	NEW	$1,248
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Allergy and Infectious Diseases Research	000	1	3/30/2026	NEW	$75,052
														Subtotal = $76,300

Grand Total All Awards = $76,300

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Exacerbation of Coxsackievirus B3-Induced Pancreatitis by NOD2 Autoregulation Across the Gut-Pancreas Axis

Award Number: F32AI197527

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 04/01/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2029

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