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ROLE OF STAT5 AND BCL-XL IN HUMAN B CELL SURVIVAL

Award Number: F32AI063846
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/01/2005
PERIOD OF PERFORMANCE END DATE: 08/31/2008

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ROLE OF STAT5 AND BCL-XL IN HUMAN B CELL SURVIVAL - DESCRIPTION (provided by applicant): Interleukin (IL)-2 and IL-4 are important for the growth of human primary B cells. These cytokines activate signal transducer and activator of transcription (STAT) 5. However, the role of STAT5 in normal human B cell growth is not completely clear. Our preliminary data suggest that activation of STAT5 promotes survival of normal human B cells. STAT5 is known to regulate expression of anti-apoptotic Bcl-xL. We, therefore, propose that STAT5 prevents normal B cell apoptosis through upregulation of Bcl-xL. In the first aim of this proposal we will investigate whether STAT5 supports B cell growth through inhibition of apoptosis by using overexpression and RNA interference approaches. In the second aim of this proposal we will investigate whether STAT5 can regulate B cell apoptosis through upregulation of Bcl-xL and we will determine the requirement for Bcl-xL in STAT5-mediated protection from apoptosis. Lastly we will identify new STAT5-regulated anti-apoptotic genes in addition Bcl-xL through RT-MLPA, a novel gene expression analysis method. Findings from this proposal will provide insight into the control of normal human B cell growth and may provide new targets for treatment of B cell malignancies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $7,000 )
2008	2008	ACADEMIC MEDICAL CENTER	MEIBERGDREEF 15	AMSTERDAM		11000		NLD	Allergy and Infectious Diseases Research	001	3	1/11/2008	NON-COMPETING CONTINUATION	$7,000
														Subtotal = $7,000

Issue Date FY: 2007 ( Subtotal = $52,048 )
2007	2007	UNIVERSITY OF AMSTERDAM	tgnih05.08	AMSTERDAM				NLD	Allergy and Infectious Diseases Research	000	3	8/16/2007	NON-COMPETING CONTINUATION	$45,048
2007	2007	ACADEMIC MEDICAL CENTER	MEIBERGDREEF 15	AMSTERDAM		11000		NLD	Allergy and Infectious Diseases Research	001	2	4/2/2007	NON-COMPETING CONTINUATION	$7,000
														Subtotal = $52,048

Issue Date FY: 2006 ( Subtotal = $43,428 )
2006	2006	UNIVERSITY OF AMSTERDAM	tgnih05.08	AMSTERDAM				NLD	Allergy and Infectious Diseases Research	000	2	8/1/2006	NON-COMPETING CONTINUATION	$43,428
														Subtotal = $43,428

Issue Date FY: 2005 ( Subtotal = $48,296 )
2005	2005	ACADEMIC MEDICAL CENTER	MEIBERGDREEF 15	AMSTERDAM				NLD	Allergy and Infectious Diseases Research	001	1	8/19/2005	NEW	$6,500
2005	2005	UNIVERSITY OF AMSTERDAM	tgnih05.08	AMSTERDAM				NLD	Allergy and Infectious Diseases Research	000	1	7/27/2005	NEW	$41,796
														Subtotal = $48,296

Grand Total All Awards = $150,772

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ROLE OF STAT5 AND BCL-XL IN HUMAN B CELL SURVIVAL

Award Number: F32AI063846

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/01/2005

PERIOD OF PERFORMANCE END DATE: 08/31/2008

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