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Define the Role of Astrocytic ADGRG1 in Protective Glial Response to Amyloid beta Pathology

Award Number: F32AG102013
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 03/14/2027
PERIOD OF PERFORMANCE END DATE: 03/13/2028

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Define the Role of Astrocytic ADGRG1 in Protective Glial Response to Amyloid beta Pathology - PROJECT ABSTRACT neurofibrillary tangles are two major dise pathogenesis. However, it is elusive how these two major glial cells communicate in setting of deposition. The adhesion G protein-coupled receptor ADGRG1 is highly expressed in astrocytes. Intriguingly, our preliminary studies showed that deleting astrocytic Adgrg1 worse in part through impairing clearance. This project aims to elucidate how astrocytic mediates protective glial responses by facilitating astrocyte- histological and single- nd transcriptomic changes in; 5xFAD; Adgrg1fl/fl; Aldh1l1Cre/+ ( Aldh1l1Cre/+ ( -Astro-Con -Astro-cKO , compared to Adgrg1+/+; we will carry out mechanistic studies in vitro using human iPSC-derived e will investigate if astrocytic regulates microglial function through contact-dependent or contact-independent mechanisms via co-culture, Transwell, and conditioned media assays, complemented by secretomics and surfaceomics to identify key communication e success of the proposed research will uncover astrocytic offering insights into glia-specific neuroprotection, laying the foundation for future translational exploration targeting .


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $76,300 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	1	9/14/2026	NEW	$76,300
														Subtotal = $76,300

Grand Total All Awards = $76,300

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Define the Role of Astrocytic ADGRG1 in Protective Glial Response to Amyloid beta Pathology

Award Number: F32AG102013

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 03/14/2027

PERIOD OF PERFORMANCE END DATE: 03/13/2028

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