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VESICULAR TRANSPORT OF THE AMYLOID PRECURSOR PROTEIN

Award Number: F32AG023990
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: PLANNING
PERIOD OF PERFORMANCE START DATE: 03/01/2004
PERIOD OF PERFORMANCE END DATE: 05/15/2007

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VESICULAR TRANSPORT OF THE AMYLOID PRECURSOR PROTEIN - DESCRIPTION (provided by applicant): One of the primary characteristics of Alzheimer's disease (AD) is senile plaques containing Ab which is formed by the processing of amyloid precursor protein (APP). Intracellular transport plays a crucial role in APP processing, but the mechanisms involved in controlling APP intracellular traffic remain insufficiently characterized. Two proteins, Mints and FE65 play opposite roles in APP processing: Mints inhibit and FE65 increases the production of Ab. Recent data suggest that Mints may function as a vesicular coat protein and thus Mints may regulate APP processing by controlling APP traffic. This proposal will establish biochemical assays that will define the molecular components involved APP vesicular trafficking. Membrane recruitment assays will be used to test the hypothesis that APP acts as a cargo receptor that recruits Mints to the membrane in an ARF-dependent manner that is prevented by FE65. In vitro budding assays will be performed to determine if the budding of APP-containing vesicles requires ARF and Mints. Because APP processing depends on APP trafficking, these data will elucidate the mechanisms by which APP is targeted to a nonpathogenic pathway and consequently identify novel therapeutic targets for AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2006 ( Subtotal = $50,428 )
2006	2006	YALE UNIVERSITY, SCHOOL OF MEDICINE	451 COLLEGE STREET, POB 1931	NEW HAVEN	CT	06409		USA	Aging Research	000	4	2/27/2006	NON-COMPETING CONTINUATION	$50,428
														Subtotal = $50,428

Issue Date FY: 2005 ( Subtotal = $48,296 )
2005	2005	YALE UNIVERSITY, SCHOOL OF MEDICINE	451 COLLEGE STREET, POB 1931	NEW HAVEN	CT	06409		USA	Aging Research	000	3	9/12/2005	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$36,106
2005	2005	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	2	2/28/2005	NON-COMPETING CONTINUATION	$12,190
														Subtotal = $48,296

Issue Date FY: 2004 ( Subtotal = $42,976 )
2004	2004	EMORY UNIVERSITY	1784 N DECATUR RD,S 530 NDBLDG	ATLANTA	GA	30322	DEKALB	USA	Aging Research	000	1	2/5/2004	NEW	$42,976
														Subtotal = $42,976

Grand Total All Awards = $141,700

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VESICULAR TRANSPORT OF THE AMYLOID PRECURSOR PROTEIN

Award Number: F32AG023990

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: PLANNING

PERIOD OF PERFORMANCE START DATE: 03/01/2004

PERIOD OF PERFORMANCE END DATE: 05/15/2007

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