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Cervical Remodeling in the Postpartum Period

Award Number: F31NR019716
ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 09/21/2020
PERIOD OF PERFORMANCE END DATE: 01/20/2024

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Cervical Remodeling in the Postpartum Period - ABSTRACT 380,000 infants are born preterm each year and account for 67% of infant deaths. Currently, there are no early, reliable, non-invasive indicators to determine the risk for spontaneous preterm birth before symptoms arise. Nevertheless, women who have delivered prematurely are at a 30% increased risk of recurrent preterm birth making a previous spontaneous preterm birth the strongest known risk factor for recurrence. Recently, investigators have reported that women who deliver spontaneous preterm have decreased collagen concentration and increased collagen disorganization early in gestation that can contribute to a mechanically weak cervix; however, the process of cervical remodeling after delivery is poorly understood and only a few studies have investigated collagen concentration and organization after birth. Due to a lack of noninvasive technology, it was never before possible to evaluate human cervical microstructure without a biopsy. For the first time, the opportunity to measure the collagen and elastic properties of the cervix noninvasively is possible with quantitative ultrasound (QUS). Innovative, noninvasive QUS technology specialized to detect microstructure changes in tissue has shown promise in detecting cervical changes in the pregnant rat cervix and in human pilot studies. In this prospective, longitudinal study, the aim is to determine the feasibility of conducting a yearlong study that evaluates whether changes in human cervical remodeling that led to spontaneous preterm birth continued in the postpartum period. Furthermore, investigators will attempt to fill the scientific gap in knowledge by determining if low ultrasound biomarkers (attenuation, backscatter coefficient, and shear wave speed) during pregnancy and postpartum were associated with spontaneous preterm birth. Ultimately, the goal is to determine the feasibility of conducting the study and to determine if ultrasound biomarkers will provide a scientific basis to accurately identify women at risk for recurrent spontaneous preterm birth.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	4	11/27/2024	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $20,041 )
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	3	5/24/2023	SUPPLEMENT FOR EXPANSION	$1,042
2023	2023	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD AVE M/C 551	CHICAGO	IL	60612	COOK	USA	Nursing Research	001	4	8/15/2023	NON-COMPETING CONTINUATION	$18,999
														Subtotal = $20,041

Issue Date FY: 2022 ( Subtotal = $46,752 )
2022	2022	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	3	8/10/2022	NON-COMPETING CONTINUATION	$46,752
														Subtotal = $46,752

Issue Date FY: 2021 ( Subtotal = $46,036 )
2021	2021	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Nursing Research	001	2	9/10/2021	NON-COMPETING CONTINUATION	$46,036
2021	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	1	11/11/2020	NEW	$0
														Subtotal = $46,036

Issue Date FY: 2020 ( Subtotal = $45,520 )
2020	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Nursing Research	001	1	9/17/2020	NEW	$0
2020	2020	UNIVERSITY OF ILLINOIS	809 S MARSHFIELD RM 520	CHICAGO	IL	60612	COOK	USA	Nursing Research	000	1	9/17/2020	NEW	$45,520
														Subtotal = $45,520

Grand Total All Awards = $158,349

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Cervical Remodeling in the Postpartum Period

Award Number: F31NR019716

ORGANIZATION: NATIONAL INSTITUTE OF NURSING RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 09/21/2020

PERIOD OF PERFORMANCE END DATE: 01/20/2024

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