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Unraveling Cerebellar Contributions to Schizophrenia Spectrum Disorders: Integrating Function, Structure, and Iron Content

Award Number: F31MH143451
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS
PERIOD OF PERFORMANCE START DATE: 11/01/2026
PERIOD OF PERFORMANCE END DATE: 10/31/2027

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Unraveling Cerebellar Contributions to Schizophrenia Spectrum Disorders: Integrating Function, Structure, and Iron Content - Project Summary: Schizophrenia Spectrum Disorders (SSD) are severe, chronic psychiatric conditions that impair cognitive functioning and sensorimotor coordination, affecting approximately 3.5% of the population. While existing treatments primarily address positive symptoms, negative symptoms, and cognitive impairments remain largely unresponsive to current interventions. Cognitive deficits, often more debilitating than positive symptoms, serve as significant predictors of long-term disability and diminished quality of life. Consequently, there is an urgent need for new approaches targeting cognitive dysfunction in SSD. Recent studies underscore the cerebellum’s involvement in cognitive functions such as attention and memory, which are disrupted in SSD. Traditionally linked to motor control, the cerebellum also plays a crucial role in cognitive processing, emotional regulation, and social behavior. However, its precise contribution to SSD remains poorly understood. This study seeks to bridge this gap by examining the cerebellum’s role in SSD through multimodal neuroimaging techniques, including resting-state functional MRI (rsfMRI), diffusion MRI (dMRI), and multi-echo gradient (mGRE) imaging. The research will compare young adults with early-stage SSD to healthy controls, investigating how cerebellar abnormalities contribute to cognitive deficits and identifying potential biomarkers for early intervention. By focusing on early-stage SSD, this study aims to identify biomarkers associated with cerebellar dysfunction in individuals with schizophrenia, laying the groundwork for future diagnostic tools and targeted treatments. The fellowship will provide advanced training in neuroimaging, data analysis, and clinical applications under the mentorship of Dr. Mariana Lazar, equipping the researcher with the expertise needed to become an independent investigator in the field. The potential impact of this research is substantial, offering novel insights into the cerebellum’s role in early-stage SSD and paving the way for innovative treatments to enhance cognitive outcomes and overall quality of life for individuals affected by the disorder.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $50,114 )
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Mental Health Research Grants	000	1	4/6/2026	NEW	$50,114
														Subtotal = $50,114

Grand Total All Awards = $50,114

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Unraveling Cerebellar Contributions to Schizophrenia Spectrum Disorders: Integrating Function, Structure, and Iron Content

Award Number: F31MH143451

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: FELLOWSHIP/SCHOLARSHIP/STUDENT LOANS

PERIOD OF PERFORMANCE START DATE: 11/01/2026

PERIOD OF PERFORMANCE END DATE: 10/31/2027

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